Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells

Launched by JONSSON COMPREHENSIVE CANCER CENTER · Sep 26, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging technique that combines MRI and PET scans to help understand how brain tumors, specifically glioblastomas, use sugar for energy. This method aims to provide important information about the tumor's characteristics, which could help doctors make better treatment decisions. Participants in the trial will have imaging done before their surgery, and then doctors will collect tissue samples from the tumor to compare the imaging results with the actual biology of the tumor.

To be eligible for this study, participants must be over 18 years old and have either newly diagnosed or recurrent glioblastoma that requires surgery. However, those who cannot undergo MRI or PET scans, or who have certain medical devices that could pose safety risks, will not qualify. If you decide to participate, you can expect to have imaging done and then provide a tissue sample during your surgery, which will help researchers learn more about the tumor's behavior and potentially improve future treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \> 18
• • Patients with newly diagnosed or recurrent glioblastoma clinically indicated for resective surgery
• Exclusion Criteria:
• • Patients who cannot obtain an MRI or FDG PET scan with contrast
• • Those with ferromagnetic implanted devices that might produce a safety hazard (e.g. infusion pumps, pace makers, aneurysm clips, etc.) will be excluded from the study along with subjects with severe claustrophobia or who have severely compromised renal function (GFR \< 30).