Effect of Timed-Restricted Eating on Metabolic Health

Launched by ACADEMISCH MEDISCH CENTRUM - UNIVERSITEIT VAN AMSTERDAM (AMC-UVA) · Sep 24, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a specific eating schedule called timed-restricted eating on health issues related to obesity and insulin resistance, which is when your body doesn't respond well to insulin, a hormone that helps manage blood sugar. The goal is to see how this eating pattern affects things like liver fat, inflammation, sleep quality, and brain function in people who have these conditions.

The trial is looking for people aged 18 to 65 who have a body mass index (BMI) over 30, which indicates obesity, and who also show signs of insulin resistance or prediabetes. To participate, individuals must have maintained a stable weight for three months before joining the study and must be healthy enough to give consent. Participants will follow a structured eating plan, and their progress will be monitored throughout the study. If you or someone you know is interested, it’s important to note that certain medical conditions, medication use, and lifestyle factors, like smoking or intense exercise, may exclude someone from participating.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ability to provide informed consent;
• • BMI \> 30kg/m\^2;
• • Insulin resistance, as defined by fasting plasma insulin \> 62 pmol/L and/or prediabetes, as defined by fasting plasma glucose \> 5.3 and \< 7.0 mmol/L;
• • Stable weight for 3 months prior to study inclusion
• • For women, 1 year after last menstrual cycle
• Exclusion Criteria:
• • Use of any medication, except for those related to treatment of metabolic syndrome;
• • Any medical condition interfering with study outcomes or design;
• • History of any psychiatric disorder, including eating disorders;
• • Performing shift work
• • Performing intensive sports (\>3 hours/week);
• • Smoking;
• • Drugs abuse or alcohol abuse (\>3 units/day);
• • Contraindication for MRI;
• • Known lactose/gluten intolerance;
• • Known soy, egg, milk or peanut allergy;
• • Childhood onset of obesity