Fish Oil-derived Omega-3 Fatty Acids on Gut Microbiota and Lipid Metabolome in Type 2 Diabetes Mellitus
Launched by SOUTHEAST UNIVERSITY, CHINA · Sep 23, 2023
Trial Information
Current as of October 01, 2025
Completed
Keywords
ClinConnect Summary
The pathogenesis of diabetes is associated with perturbations in lipid metabolism and intestinal flora. Nevertheless, the precise impact of Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) on key lipid metabolites, intestinal microorganisms, and fungi linked to type 2 diabetes remains indeterminate. The objective of this research was to investigate the impact of Omega-3 PUFAs on the gut microbiota and serum lipid metabolites in participants diagnosed with type 2 diabetes, employing high-throughput sequencing technology and untargeted lipidomics. The investigators randomly allocated 110 e...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients with type 2 diabetes have been diagnosed;
- • Male or female aged 18-70 years;
- • After listening to the project presentation, voluntarily participate in the study and sign an informed consent form.
- Exclusion Criteria:
- • Pregnant or lactating women;
- • Poorly controlled diabetes, i.e. HbA1c\>9%；
- • Have taken omega-3 PUFAs-related supplements in the past six months；
- • Taking lipid-lowering drugs or other drugs that affect blood lipid metabolism；
- • Patients with severe diabetic complications, severe hypertension, combined with
- • diseases of the heart, brain, liver, kidney, thyroid and hematopoietic system, psychosis；
- • Patients with severe immune system disorders；
- • Have special diets: vegetarians, weight managers, ketogenic test takers, etc；
- • The attending physician deems the participant unsuitable
About Southeast University, China
Southeast University, located in Nanjing, China, is a prestigious institution renowned for its commitment to advancing medical research and clinical innovation. With a strong emphasis on interdisciplinary collaboration, the university leverages its robust academic resources and state-of-the-art facilities to conduct clinical trials that aim to address pressing healthcare challenges. Southeast University actively engages in partnerships with healthcare organizations and industry leaders to facilitate cutting-edge research, enhance patient outcomes, and contribute to the global medical community. Through its dedicated focus on ethical standards and scientific rigor, Southeast University is poised to make significant contributions to the field of clinical research.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Nanjing, Jiangsu, China
Lianshui, Jiangsu, China
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported