Clinical and Microbiological Aspects of Probiotics in Non-surgical Periodontal Therapy.

Launched by G. D'ANNUNZIO UNIVERSITY · Sep 26, 2023

Keywords

ClinConnect Summary

This clinical trial is studying whether taking specific probiotics—Lactobacillus rhamnosus LR04 and Lactobacillus plantarum LP14—can help people with moderate to severe gum disease, known as periodontitis. The researchers want to find out if these probiotics can improve gum health when taken alongside regular oral hygiene practices, like brushing and flossing. Participants will be divided into three groups: one group will take the probiotics for 90 days, another will receive a placebo (which looks like the probiotics but has no active ingredients), and the last group will only follow their usual oral care routine without any additional treatment.

To participate in this study, individuals should be between 65 and 74 years old, and they must not have any serious health conditions like diabetes or autoimmune diseases. They should also not be current drinkers or have taken probiotics in the last three months. If eligible, participants can expect to take the assigned treatment for 90 days and regularly check in with the researchers about their gum health. This trial is not yet recruiting, so it’s a good time to learn more about it if you or someone you know is dealing with gum issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients in the absence of other systemic pathologies reported in the medical history
• • smokers and non-smokers, non-drinkers,
• • subjects in the absence of previous or current administration of other sources of probiotics,
• • subjects capable of providing informed consent.
• Exclusion Criteria:
• • Subjects with a history of systemic diseases (diabetes, autoimmune diseases, inflammatory bowel diseases, neurodegenerative diseases),
• • drinkers,
• • subjects who take or have taken probiotics in the last 3 months,
• • subjects unable to provide informed consent.