Early-life MRI Biomarkers of Longer-term Respiratory Morbidity in Infants Born Extremely Preterm (EMBLEM)

Launched by CHILDREN'S HOSPITAL OF EASTERN ONTARIO · Sep 27, 2023

Keywords

ClinConnect Summary

The EMBLEM clinical trial is studying how new MRI techniques can help predict long-term lung problems in infants born extremely premature, specifically those born before 29 weeks of pregnancy. The focus is on understanding conditions like bronchopulmonary dysplasia (BPD), a serious lung issue that can affect premature babies. By using advanced MRI scans, researchers will look at the structure of the lungs and blood vessels in these infants at 36 weeks after conception to identify early signs of lung disease. This knowledge could help doctors better care for the most vulnerable babies and guide families on what to expect in the future.

To be eligible for the trial, infants must be less than 29 weeks old at birth and under 36 weeks post-menstrual age. Unfortunately, babies with certain lung or heart conditions, genetic syndromes, or those who cannot safely undergo an MRI won't be able to participate. Throughout the study, which includes regular check-ins and assessments of lung health and development, participants can expect a supportive environment where their health is closely monitored. This research aims to improve future treatments for lung issues in premature infants and ultimately enhance their long-term health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Infants born at \<29 weeks gestation;
• • 2. currently \<36 weeks PMA.
• Exclusion Criteria:
• • 1. Known interstitial lung disease, congenital lung anomaly, ciliary dysfunction, immunodeficiency, cystic fibrosis, neuromuscular disease, or structural heart disease (other than atrial septal defect/hemodynamically insignificant ventricular septal defect/patent ductus arteriosus);
• • 2. genetic syndrome or congenital anomaly;
• • 3. contraindications for MRI or transport;
• • 4. invasive or non-invasive ventilation that cannot be safely removed for MRI;
• • 5. current respiratory infection;
• • 6. family cannot speak English/French;
• • 7. transferred to another hospital prior to baseline study visit
• • 8. not receiving follow-up at one of the study centres.