Exploring Cancer-Associated Thromboembolism Prognosis Biomarkers and Polymorphisms

Launched by LEBANESE UNIVERSITY · Sep 29, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how certain biological markers and genetic variations relate to blood clots that can occur in people with cancer, especially those with colorectal cancer. The researchers want to understand how the immune system and inflammation affect these blood clots, which can complicate cancer treatment. By identifying these markers, the study aims to find new ways to help patients who experience blood clots during their cancer journey, potentially improving their responses to treatments like chemotherapy and immunotherapy.

To be eligible for this trial, participants should be over 18 years old, diagnosed with a specific type of early-stage cancer (like colorectal cancer), and have no prior cancer treatments. The trial is open to both men and women of white ethnicity. If you join, you can expect to undergo tests to help researchers learn more about your condition while contributing to important discoveries in cancer treatment. It’s also important to note that people with more advanced cancer stages or certain health conditions may not be eligible to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individuals of white ethnicity.
• • Age between \> 18
• • Both males and females.
• • Diagnosis of selected cancer type (e.g., colorectal cancer).
• • Cancer stage 0/I/II without metastasis or lymph node dissemination at the time of enrollment.
• • No previous cancer therapy (radiotherapy, chemotherapy, or immunotherapy) received before study enrollment.
• • Unrelated patients.
• Exclusion Criteria:
• • Cancer stage III/IV.
• • History of hematological cancer types or previous cancers, recurrent or relapse.
• • Diagnosis of inflammatory bowel diseases.
• • Pre-existing cardiovascular diseases or coronary artery diseases.
• • Confirmed treated or untreated autoimmune diseases.
• • Metabolic disorders, diabetes, or hypertension.
• • Neurological diseases.
• • Evidence of cardiac, renal, bone, or cerebral damage.
• • Presence of more than one type of malignancies.
• • Active infections or myositis.
• • Familial polyposis.
• • Alcohol or smoking habits.
• • Colon-affecting food allergies.
• • Body mass index (BMI) \>30.
• • Significant weight loss within the last 2 years.
• • History of abdominal surgeries.
• • Pregnancy.
• • Related patients.