miRNAs in Critical Limb Ischemia (miRNACLI)

Launched by IRCCS POLICLINICO S. DONATO · Sep 27, 2023

Keywords

ClinConnect Summary

The miRNAs in Critical Limb Ischemia (miRNACLI) trial is studying a serious condition called critical limb ischemia (CLI), which causes severe pain and can lead to amputations in the legs due to poor blood flow. The study involves 80 patients: 40 with CLI who are undergoing surgery for their condition, and 40 who have a different issue (abdominal aortic aneurysm) but do not have CLI. Researchers will collect tissue samples from both groups of patients to analyze specific molecules called miRNAs, which may help understand the disease better and improve treatments in the future.

To be eligible, you must be an adult patient with CLI who is scheduled for surgery, or a patient with an abdominal aortic aneurysm who is undergoing a specific type of surgery and does not have CLI. Unfortunately, pregnant women, those with certain genetic diseases, or cancer patients cannot participate. If you join the study, you can expect to provide a biopsy, which is a small sample of tissue, to help researchers gather important information about your condition. This study is currently looking for participants, and being part of it may contribute to developing new ways to treat CLI.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Cases:
• • patients affected by CLI candidates for popliteal exploration surgery and/or subgenual femoropopliteal bypass.
• • Patients affected by CLI with irreversible ischemia and/or distal gangrene of the lower limb candidates for major amputation of the lower limb.
• Controls:
• • • patients affected by infrarenal abdominal aortic aneurysm (AAA) undergoing endovascular exclusion surgery of the AAA (EVAR) who are free from CLI, affected and not affected by type 2 diabetes mellitus.
• Exclusion Criteria:
• • Pregnant women
• • Patients carriers of genetic diseases
• • Patients suffering from malignant neoplasia