Prophylactic Pregabalin Treatment Following Spinal Cord Injury

Launched by LOEWENSTEIN HOSPITAL · Sep 28, 2023

Keywords

ClinConnect Summary

This clinical trial is studying whether taking a medication called Lyrica (also known as Pregabalin) can help prevent pain after a spinal cord injury (SCI). The trial involves patients who are starting rehabilitation within three months after their injury. Participants will be divided into two groups: one group will receive Lyrica, while the other group will not. Researchers will then monitor both groups to see if Lyrica helps reduce the chance of developing central pain, which is a type of pain that can occur after spinal cord injuries.

To be eligible for this trial, participants should be between the ages of 65 and 74, and they must have had a spinal cord injury within the last three months. They also need to be able to understand the study and agree to participate. However, individuals who are pregnant, have certain medical conditions that affect sensation, or have had similar pain before the trial won't be able to join. If someone participates, they can expect regular follow-ups to check on their pain levels and overall health during the study. This trial is currently recruiting participants, and everyone's involvement will help researchers better understand pain management after spinal cord injuries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Up to 3 months following traumatic or non-traumatic SCL
• • Ability to give informed consent and cooperate
• Exclusion Criteria:
• • Pregnancy
• • Neurological or other medical conditions that may interfere with sensation
• • Neuropathic-like pain before recruitment (described as painful sensation of electric current, burning, numbness, tingling, pricking, or squeezing)
• • Being treated with Pregabalin
• • Blood creatinine levels \>1.2 or creatinine clearance \<60
• • Sensitivity to lactose