Cardiac Biomarkers for the Quantification of Myocardial Damage After Cardiac Surgery

Launched by JENA UNIVERSITY HOSPITAL · Sep 28, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how certain heart proteins, known as cardiac biomarkers (specifically troponin I, troponin T, and CK-MB), are released during and after heart surgery. The main goal is to see if the levels of these proteins can reliably indicate heart damage and how their levels change over time after surgery. This information is important because it could help improve guidelines for diagnosing heart issues, particularly for patients undergoing valve surgeries.

To participate in this trial, you should be at least 18 years old and scheduled for isolated surgery on the aortic or mitral valve. However, if you have had coronary artery disease recently, have certain allergies, or have specific medical conditions that would make an MRI difficult, you won't be eligible to join. If you do take part, you can expect close monitoring of your heart biomarkers during your surgery and recovery, which may help doctors better understand heart health in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Indication for isolated aortic or mitral valve surgery
• • Written informed consent
• • Age ≥ 18 years
• Exclusion Criteria:
• • Presence of coronary artery disease (excluded within the last 6 months)
• • Allergy to gadolinium
• • Cochlear implant
• • Deep brain stimulation
• • Individual factors excluding the performance of an MRI (e.g. claustrophobia of the patient)
• • Significantly reduced renal function (GFR \< 30ml/min)
• • Perioperative complications that may lead to myocardial damage (discontinuation of the study for the patient and exclusion from the analysis after primary study inclusion)
• • Need for extension of surgery (additional procedures on other heart valves, aorta, myocardium, or similar; exclusion after primary study inclusion possible)
• • Pregnancy or lactation