Selective Reporting for Antibiotic Susceptibility Testing and GPs' Prescribing of Broad-spectrum Antibiotics in Women With E. Coli UTIs

Launched by NANTES UNIVERSITY HOSPITAL · Sep 28, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how a new way of reporting antibiotic test results can help doctors prescribe the right antibiotics for women with urinary tract infections (UTIs) caused by E. coli. The trial compares a selective reporting method, which gives doctors a tailored list of effective antibiotics based on the specific bacteria's resistance, to standard reporting. The goal is to see if this approach can reduce the use of broad-spectrum antibiotics, which are often over-prescribed and can contribute to antibiotic resistance.

To participate in the trial, women must be at least 18 years old, live in certain regions of France, and have a positive urine culture for E. coli that was tested by a specific lab. General practitioners involved in the study must have treated a significant number of patients and received urine culture results from the same lab. Participants can expect to help researchers understand whether this new reporting method can lead to better antibiotic prescribing practices and ultimately improve treatment for UTIs.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• Patients :
• • women ≥18 years of age,
• • affiliated with the CPAM of Loire Atlantique (44) or Maine et Loire (49),
• • with a urine culture: i) analyzed by LabOuest, ii) positive for E. coli, and iii) associated with a prescription for antibiotics by a general practitioner in the period 7 days before and 14 days after the antibiotic susceptibility testing.
• General practitioners :
• • practicing in primary care Loire Atlantique (44) and/or Maine et Loire (49),
• • having been consulted by at least 100 different patients in the 12 months prior to baseline,
• • having received at least one urine culture result for a woman ≥18 years of age analyzed by LabOuest over the 12 months prior to baseline.
• Exclusion Criteria:
• Patients :
• • hospitalized in the period 7 days before and 14 days after antibiotic susceptibility testing (data on antibiotics dispensed in healthcare institutions are not accessible via DCIR data),
• • with reimbursements for antibiotics prescribed by physicians in different practices over the period 7 days before and 14 days after antibiotic susceptibility testing.
• General practitioners :
• • with a special practice (acupuncture, allergology, angiology).
• • not receiving any urine culture results analyzed by a laboratory of the LabOuest network in the year following the intervention