Intradermal Influenza Vaccination

Launched by YALE UNIVERSITY · Sep 27, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how the body responds to a specific type of flu vaccine that is given through the skin instead of the usual injection into the muscle. Researchers want to understand how both the immediate and long-term immune responses develop in healthy individuals after receiving this vaccine. Participants will receive the vaccine using a special device called MicronJet, and researchers will collect samples from their skin and blood to measure various immune responses over time.

To be eligible for this trial, participants need to be healthy adults aged 18 to 40 who can read, write, and speak English. They should not have any recent serious health issues, allergies to vaccine components, or have received certain vaccines in the past few months. If you decide to participate, you can expect to attend several visits where your health will be monitored, and various samples will be taken to help researchers learn more about how this new vaccination method works. Additionally, this study is currently recruiting participants, so it's an opportunity to contribute to important research on flu vaccinations.

Gender

ALL

Eligibility criteria

• In order to be eligible to participate in this study, an individual must meet all of the following criteria:
• • 1. Provision of signed and dated informed consent form
• • 2. Stated willingness to comply with all study procedures and availability for the duration of the study, as well as have deidentified samples and data stored for future research.
• • 3. Able to proficiently speak, read, and write English.
• • 4. Male or female, aged 18-40 years old at time of initial enrollment
• • a. Participant is allowed to participate in subsequent influenza seasons even if they will be \>40 years old.
• • 5. In good general health as evidenced by medical history
• Individuals meeting any of the following criteria will be excluded from study participation:
• • 1. CBC with differential, lymphocyte phenotyping with T, B, and natural killer cells (TBNK), complete metabolic panel, anti-CMV immunoglobulin (Ig) G and IgM, and/or anti-Epstein-Barr virus (EBV) antibody panel values outside of the Yale Department of Laboratory Medicine normal reference ranges and deemed clinically significant by the PI at the time of screening.
• • 2. Positive result for anti-HIV 1/2 antibody screening at the time of screening.
• • 3. Prior receipt of a current seasonal influenza vaccine (for the season of participation).
• • 4. History of allergy or hypersensitivity to any components of the study vaccine (e.g., egg protein).
• • 5. History of severe reactions to vaccines.
• • 6. Use of an oral glucocorticoid within the past 30 days.
• • 7. Receipt of a live-attenuated vaccine within the past 3 months.
• • 8. Receipt of any experimental vaccine.
• • 9. Receipt of any other type of vaccine (non-live and non-experimental, e.g., tetanus, diphtheria, and pertussis \[TDaP\]) within the past 3 months.
• • 10. Planned vaccination before day 100 after study vaccination.
• • 11. Current or recent use (within the past 90 days) of immunoglobulin therapy.
• • 12. Surgery within the past 8 weeks, or planned surgery before day 28.
• • 13. Current (within the past 30 days) treatment for active malignancy.
• • 14. Cancer chemotherapy in the past 2 years.
• • 15. Administration of any blood products within 90 days of the screening, or planned administration before day 100.
• • 16. History of parasitic, amebic, fungal, or mycobacterial infections within the past 1 year, with the exception of tinea pedis and onychomycosis.
• • 17. History of autoimmune or autoinflammatory disease.
• • a. In particular skin-related (i.e. psoriasis, lichen planus, lupus, neutrophilic dermatoses, atopic dermatitis)
• • 18. History of keloids
• • 19. History of a bleeding disorder.
• • 20. Current use (within the past 30 days) of illicit drugs (per subject report), with the exception of marijuana.
• • 21. Current alcohol use disorders (criteria per Diagnostic and Statistical Manual of Mental Disorders, fifth edition), within the past 30 days.
• • 22. Serious, ongoing, uncontrolled infection within the past 30 days as per the judgement of the PI.
• • 23. History of Guillain-Barre syndrome (GBS).
• • 24. BMI ≥ 30.
• • 25. Known or suspected immunodeficiency within 1 year, including documented HIV infection.
• • 26. Pregnancy or planning to become pregnant during the study period. (Women of childbearing potential must have a negative urine or serum pregnancy test at screening.)
• • 27. Presence of conditions that, in the judgment of the PI, may put the individual at undue risk or compromise the scientific objectives of the study.
• • Co-enrollment guidelines: Co-enrollment in other trials is restricted, other than enrollment on observational studies. Consideration for co-enrollment in trials evaluating the use of a licensed medication will require the approval of the PI. Study staff should be notified of co-enrollment on any other protocol as it may require the approval of the PI.