Weight Loss Following an Episode of Pre-eclampsia Using a Dissociated or Hypocaloric Diet in Overweight or Obese Patients

Launched by CENTRE HOSPITALIER LE MANS · Sep 28, 2023

Keywords

ClinConnect Summary

The POPADIPE study is looking at ways to help overweight and obese women who have experienced pre-eclampsia—a serious pregnancy complication—lose weight safely. The main goal is to help these women reduce their body weight without losing muscle. Participants in the trial can choose between two types of diets: a lower-calorie diet or a dissociated diet, which focuses on eating certain food combinations. This research is important because it aims to improve the health of women who have had pre-eclampsia, which can lead to long-term health issues like kidney disease.

To join the study, participants must be women aged 18 to 45, have experienced pre-eclampsia in the past five years, and have a body mass index (BMI) between 25 and 40. They also need to agree to follow a diet plan. However, women with certain conditions or those who are pregnant or breastfeeding cannot participate. If eligible, participants can expect support from dietitians as they work on their weight loss journey in a structured and monitored environment. This trial is currently recruiting participants, and it aims to find effective ways to manage weight after pre-eclampsia.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Person affiliated to social security
• • Free, informed and written consent signed by the participant and the investigator (no later than the day of day of inclusion and before any examination required by the research)
• • Patient over 18 years of age at the time of inclusion and \< 45 years of age
• • Having had an pre-eclampsia in the last 5 years according to the definitions of the ISSHP 2018
• • Patient with a BMI between 25 kg/m² and 40 kg/m² who accepts dietetic follow up
• • Patient with a medical prescription for dietetic follow-up aimed at losing weight loss
• • Patient with a balanced diet
• Exclusion Criteria:
• • Patients with a mental disability or language barrier that prevents them from understanding or consenting to the study
• • Patients deprived of their liberty by judicial or administrative decision
• • Patients under psychiatric care
• • Patients subject to a legal protection measure
• • Patients with cognitive disorders or defined eating disorders
• • Patients who are pregnant or breast-feeding
• • Patients undergoing steroid treatment and/or immunosuppression
• • Have been on a low-calorie or dissociated diet for at least 6 months
• • Patients with CKD stage ≥ 3A