An Observational Research Study to Uncover Subtypes of Cancer Cachexia
Launched by UNIVERSITY OF ROCHESTER NCORP RESEARCH BASE · Oct 3, 2023
Trial Information
Current as of July 22, 2025
Recruiting
Keywords
ClinConnect Summary
The LOTUS-CC Study is examining a serious condition called cancer cachexia, which is the loss of weight and muscle that can occur in patients with certain types of cancer, specifically colorectal, lung, or pancreatic cancer that cannot be surgically removed. This study aims to understand how cachexia affects patients' physical abilities, symptoms, and overall quality of life. Unlike past studies that treated all patients the same way, this research recognizes that different individuals may experience weight loss for different reasons. By gathering detailed information, the researchers hope to find better ways to diagnose and treat cancer cachexia in the future.
To be eligible for this study, participants must be at least 18 years old and have been diagnosed with advanced stages of non-small cell lung cancer, pancreatic cancer, or colorectal cancer. They should be planning to start or have recently started a specific type of cancer treatment. Patients do not need to have cachexia to participate. If you join the study, you will be asked to take part in physical function tests and share information about your health. This research could lead to improved treatments and support for patients dealing with the challenges of advanced cancer and cachexia.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Have a primary diagnosis of unresectable or stage IV 1) non-small cell lung cancer (NSCLC), 2) pancreatic adenocarcinoma, or 3) colorectal cancer
- • Note: Patients do not need to have cachexia to be eligible
- • Plan to start first-line systemic anti-cancer therapy (chemotherapy, immunotherapy, targeted therapy, interventional clinical trial) in the next 6 weeks or has started first-line systemic therapy in the previous 6 weeks.
- • NOTE: Patients who received systemic anti-cancer therapy previously as part of adjuvant or neoadjuvant treatment and have since recurred are still eligible if such treatment ended \> 6 months prior to enrollment. Patients receiving concurrent radiation with systemic therapy or received local therapy alone (surgery, radiation therapy \[RT\]) prior to first line therapy remain eligible. Patients receiving maintenance treatment after first line therapy are not eligible
- • Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
- • Be able to understand, speak and read English
- • Be 18 years of age or older
- Exclusion Criteria:
- • Have contraindications to physical function assessments (30-second arm curl, Timed-Up-And-Go test, or 30-second chair-stand test) per the treating provider or their designee
- • Have any planned major surgeries within the next 3 months
- • Have received chemotherapy or surgery for separate primary cancer within the past 3 years other than early local staged non-melanoma skin cancer
- • Be pregnant
About University Of Rochester Ncorp Research Base
The University of Rochester NCORP Research Base is a leading academic institution dedicated to advancing cancer research through innovative clinical trials and community engagement. As part of the National Clinical Trials Network, it collaborates with a network of community hospitals and research sites to facilitate access to cutting-edge cancer therapies and preventative strategies for diverse patient populations. The research base focuses on improving health outcomes by integrating scientific inquiry with practical applications, emphasizing the importance of patient-centered care in oncology. Through rigorous study design and multidisciplinary collaboration, the University of Rochester NCORP Research Base aims to enhance the understanding of cancer and contribute to the development of effective treatment options.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Kalamazoo, Michigan, United States
Edina, Minnesota, United States
Waconia, Minnesota, United States
Peoria, Illinois, United States
Saint Paul, Minnesota, United States
Iron Mountain, Michigan, United States
Kalamazoo, Michigan, United States
Coon Rapids, Minnesota, United States
Renton, Washington, United States
Urbana, Illinois, United States
Minneapolis, Minnesota, United States
Saint Paul, Minnesota, United States
Shakopee, Minnesota, United States
Willmar, Minnesota, United States
Effingham, Illinois, United States
Greenville, Ohio, United States
Springfield, Illinois, United States
Downers Grove, Illinois, United States
Portland, Oregon, United States
Hazel Crest, Illinois, United States
Honolulu, Hawaii, United States
Minneapolis, Minnesota, United States
Aurora, Colorado, United States
Washington, District Of Columbia, United States
Gainesville, Georgia, United States
Savannah, Georgia, United States
Saint Louis, Missouri, United States
Newark, Delaware, United States
Kettering, Ohio, United States
Honolulu, Hawaii, United States
Saint Louis Park, Minnesota, United States
Milwaukee, Wisconsin, United States
Oak Lawn, Illinois, United States
Park Ridge, Illinois, United States
Green Bay, Wisconsin, United States
Marshfield, Wisconsin, United States
Honolulu, Hawaii, United States
Portland, Oregon, United States
Decatur, Illinois, United States
Ottawa, Illinois, United States
Peoria, Illinois, United States
Peru, Illinois, United States
Maplewood, Minnesota, United States
Maplewood, Minnesota, United States
Stillwater, Minnesota, United States
Findlay, Ohio, United States
Spartanburg, South Carolina, United States
Atlanta, Georgia, United States
Columbus, Georgia, United States
Lawrenceville, Georgia, United States
Honolulu, Hawaii, United States
Honolulu, Hawaii, United States
Galesburg, Illinois, United States
Richmond, Indiana, United States
Elkton, Maryland, United States
Woodbury, Minnesota, United States
Springfield, Missouri, United States
Boardman, Ohio, United States
Warren, Ohio, United States
Youngstown, Ohio, United States
South Hill, Virginia, United States
Vancouver, Washington, United States
Eau Claire, Wisconsin, United States
Green Bay, Wisconsin, United States
Rice Lake, Wisconsin, United States
Sheboygan, Wisconsin, United States
West Allis, Wisconsin, United States
Weston, Wisconsin, United States
Kettering, Ohio, United States
Savannah, Georgia, United States
Marietta, Ohio, United States
Bellingham, Washington, United States
Libertyville, Illinois, United States
Newberg, Oregon, United States
Oshkosh, Wisconsin, United States
New Ulm, Minnesota, United States
Denver, Colorado, United States
Denver, Colorado, United States
Las Vegas, Nevada, United States
Elgin, Illinois, United States
Canton, Illinois, United States
Carthage, Illinois, United States
Eureka, Illinois, United States
Kewanee, Illinois, United States
Macomb, Illinois, United States
Peru, Illinois, United States
Princeton, Illinois, United States
Appleton, Wisconsin, United States
Lake Success, New York, United States
Grafton, Wisconsin, United States
Ft. Smith, Arkansas, United States
Valdosta, Georgia, United States
Bloomington, Illinois, United States
Chicago, Illinois, United States
Pekin, Illinois, United States
Saint Louis, Missouri, United States
Greenville, South Carolina, United States
Burlington, Wisconsin, United States
Germantown, Wisconsin, United States
Green Bay, Wisconsin, United States
Kenosha, Wisconsin, United States
Marinette, Wisconsin, United States
Milwaukee, Wisconsin, United States
Racine, Wisconsin, United States
Summit, Wisconsin, United States
Two Rivers, Wisconsin, United States
Wauwatosa, Wisconsin, United States
Longview, Washington, United States
Oregon City, Oregon, United States
New Richmond, Wisconsin, United States
Springfield, Illinois, United States
Belpre, Ohio, United States
Newark, Delaware, United States
Newark, Delaware, United States
Rehoboth Beach, Delaware, United States
Wilmington, Delaware, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Lakewood, Colorado, United States
Thornton, Colorado, United States
Boulder, Colorado, United States
Denver, Colorado, United States
Littleton, Colorado, United States
Lone Tree, Colorado, United States
Carbondale, Illinois, United States
Carterville, Illinois, United States
Centralia, Illinois, United States
Decatur, Illinois, United States
O'fallon, Illinois, United States
Maple Grove, Minnesota, United States
Wyoming, Minnesota, United States
Sainte Genevieve, Missouri, United States
Sullivan, Missouri, United States
Cincinnati, Ohio, United States
Findlay, Ohio, United States
Franklin, Ohio, United States
Sturgeon Bay, Wisconsin, United States
Monticello, Minnesota, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Gaffney, South Carolina, United States
Greer, South Carolina, United States
Eau Claire, Wisconsin, United States
Milwaukee, Wisconsin, United States
Aiea, Hawaii, United States
Boulder, Colorado, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Beavercreek, Ohio, United States
Stevens Point, Wisconsin, United States
Winchester, Virginia, United States
Bluffton, South Carolina, United States
Hilton Head Island, South Carolina, United States
Honolulu, Hawaii, United States
Denver, Colorado, United States
Braselton, Georgia, United States
Libertyville, Illinois, United States
Centennial, Colorado, United States
Englewood, Colorado, United States
Dixon, Illinois, United States
Washington, Illinois, United States
Farmington, Missouri, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Englewood, Colorado, United States
Burnsville, Minnesota, United States
Duluth, Georgia, United States
Princeton, Minnesota, United States
Gainesville, Georgia, United States
Barrington, Illinois, United States
Crystal Lake, Illinois, United States
Cudahy, Wisconsin, United States
Springfield, Illinois, United States
Grand Rapids, Michigan, United States
Normal, Illinois, United States
Grand Rapids, Michigan, United States
Troy, Ohio, United States
Danville, Illinois, United States
Minocqua, Wisconsin, United States
Urbana, Illinois, United States
Columbus, Ohio, United States
Green Bay, Wisconsin, United States
Milwaukee, Wisconsin, United States
Oak Lawn, Illinois, United States
Sunset Hills, Missouri, United States
Tifton, Georgia, United States
O'fallon, Illinois, United States
Greenfield, Wisconsin, United States
Grand Rapids, Michigan, United States
Dayton, Ohio, United States
Millville, Delaware, United States
Aiea, Hawaii, United States
Aiea, Hawaii, United States
Ewa Beach, Hawaii, United States
Union, South Carolina, United States
Patients applied
Trial Officials
Richard F Dunne, MD
Principal Investigator
University of Rochester NCORP Research Base
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported