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Search / Trial NCT06075979

Correlation Between Microbial Infection and Lumbar Degenerative Disease Based on High-throughput Gene Sequencing

Launched by HAOXUANZHANG · Oct 4, 2023

Trial Information

Current as of July 09, 2025

Recruiting

Keywords

Lumbar Degenerative Diseases High Throughput Gene Sequencing Microbial Infection

ClinConnect Summary

This clinical trial is exploring the relationship between microbial infections and lumbar degenerative diseases, which are common conditions affecting the lower back. Researchers believe that certain low-toxicity bacteria found in the discs of the spine might play a role in the development and worsening of these diseases. They aim to use advanced gene sequencing technology to better identify these bacteria in patients' spinal tissues and blood samples, which could help them understand how infections may contribute to back problems. Ultimately, this study hopes to provide new insights for preventing and treating lumbar degenerative diseases.

To participate in this trial, individuals aged 18 to 85 who have been diagnosed with lumbar degenerative diseases and have not seen improvement from conservative treatment for three months may be eligible. Participants will undergo surgery, during which spinal disc tissue will be collected for analysis. It's important to note that individuals with existing infections, mental health issues, or allergies to metal are not eligible to join the study. Overall, this research aims to uncover important connections that could lead to better treatments for those suffering from back pain and related conditions.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients in the experimental group, aged 18 to 85 years old, have symptoms and imaging data that support the diagnosis of lumbar degenerative diseases (including lumbar disc herniation, lumbar spinal stenosis, and lumbar spondylolisthesis).
  • Patients who undergo strict conservative treatment for 3 months before surgery have no significant improvement in symptoms; The control group of patients had no significant lumbar disc degeneration evaluated by imaging, but needed surgical decompression and fusion intervention due to trauma causing lumbar fractures, lumbar tumors, scoliosis.
  • The disc organizer can be obtained during surgery.
  • Exclusion Criteria:
  • Lumbar degenerative diseases combined with infectious diseases.
  • Lumbar degenerative diseases combined with mental diseases.
  • Lumbar degenerative diseases combined with metal allergy.

About Haoxuanzhang

Haoxuanzhang is a clinical trial sponsor dedicated to advancing medical research and innovation through the design and execution of clinical studies. With a focus on enhancing patient outcomes, the organization collaborates with healthcare professionals and regulatory bodies to ensure the highest standards of quality and compliance. Haoxuanzhang is committed to exploring new therapeutic possibilities and improving existing treatment modalities across various therapeutic areas, leveraging cutting-edge methodologies and technologies to drive evidence-based advancements in healthcare.

Locations

Jinan, Shandong, China

Patients applied

0 patients applied

Trial Officials

Hao-Xuan Zhang, Ph.D/MD

Study Chair

Shandong First Medical University

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported