Sex Difference of Coronary Microvascular Dysfunction in Patients With Non-obstructive Coronary Artery Disease

Launched by KOREA UNIVERSITY ANAM HOSPITAL · Oct 6, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how men and women experience problems with small blood vessels in the heart, specifically in patients who have non-obstructive coronary artery disease. This condition can cause chest pain or other symptoms, even when the main arteries are not blocked. The researchers want to understand if there are differences between sexes in how these small blood vessels work, which could help improve treatment for patients with microvascular angina, a type of chest pain linked to these issues.

To be eligible for the trial, participants should be experiencing chest pain or similar symptoms, but their coronary arteries should not be significantly narrowed (less than 50% blockage). The trial is open to all genders and is currently recruiting patients aged 18 to 75. Participants can expect to have tests done to evaluate the function of their heart's small blood vessels. It's important to note that certain health conditions, like moderate heart valve disease or severe kidney problems, may exclude someone from joining the study. This research aims to find better ways to diagnose and treat heart issues, especially in women, who may experience different symptoms than men.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Typical/atypical chest pain or ischemic symptoms including dyspnea
• • No significant coronary artery stenosis (\<50% stenosis) in coronary angiography or computed tomography
• Exclusion Criteria:
• • ≥ Moderate valvular heart disease
• • Congenital heart disease
• • Chronic renal failure (estimated glomerular filtration rate \<30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
• • Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
• • Receiving anticancer drugs
• • Vasculitis associated with autoimmune diseases
• • Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients