Danish Angle Closure Prevention Trial

Launched by UNIVERSITY OF AARHUS · Oct 4, 2023

Keywords

ClinConnect Summary

The Danish Angle Closure Prevention Trial is studying whether a specific laser treatment, called prophylactic laser iridotomy, can help prevent serious eye problems in people who are suspected of having primary angle closure. This is particularly focused on Caucasian individuals who show signs of potential issues with fluid drainage in the eye but do not yet have glaucoma. The trial is currently looking for participants aged between 16 and 29 years who meet certain criteria, such as having a specific amount of contact between eye structures, normal eye pressure, and good vision.

If you or a family member are considering joining this trial, it's important to note that participants will need to have certain eye characteristics and meet eligibility requirements. Those who have had previous eye surgeries or have specific eye conditions like glaucoma or significant cataracts will not be eligible. Participants can expect to receive the laser treatment if they qualify, and they will be monitored throughout the study to see how well the treatment works in preventing further eye issues. This trial aims to provide valuable information that could help protect the eye health of individuals at risk.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Primary angle closure suspect: ≥180 degrees (cumulative) irido-trabecular contact on darkroom gonioscopy, IOP\<21mmHg, no peripheral anterior synechiae, no glaucomatous optic neuropathy
• • Best-corrected visual acuity (BCVA) \>0.8 on both eyes
• • Caucasian
• Exclusion Criteria:
• • Pseudophakia
• • Previous iridotomy
• • Clinically significant cataract with indication for surgery,
• • Gaucoma
• • Uveitis
• • Unstable retinal conditions
• • Ocular malignancies
• • PEX
• • PDS
• • Systemic or ocular corticosteroid treatment