The Choice of Treatment Methods and Efficacy of LABC

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · Oct 6, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring the best way to treat locally advanced breast cancer, a type of breast cancer that has spread but is still contained in the breast area. The researchers want to find out whether it is more effective to give chemotherapy (a type of cancer treatment) first and then perform surgery, or to do the surgery first and follow it with chemotherapy. To do this, they will randomly place eligible patients into one of the two groups and compare their outcomes, focusing on how long they remain free from the disease and their overall survival rates.

To participate in this trial, women aged 18 to 70 who have been recently diagnosed with locally advanced breast cancer may be eligible, provided their tumors can be surgically removed. Participants will receive the assigned treatment and will need to complete follow-up assessments to check on their quality of life and emotional well-being. It’s important to note that those with previous cancer treatments or certain health conditions may not qualify. This study aims to improve treatment options for breast cancer, and participants will play a crucial role in helping researchers understand which method works best.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. 18-70 year old female
• • 2. Patients with locally advanced breast cancer (stage IIIb - IIIc) first diagnosed;
• • 3. Clinical diagnosis of breast cancer, or puncture pathology suggests breast cancer;
• • 4. After evaluation by experienced clinical physicians, the patient's tumor has the possibility of surgical resection. Specific evaluation indicators include ultrasound assessment of the tumor not surrounding the axillary vein;
• • 5. Accept treatment plans including surgery, radiotherapy, and chemotherapy;
• • 6. Volunteer to participate in clinical research and sign an informed consent form;
• • 7. Willing to undergo follow-up and complete quality of life (EQ-5D series scale and FACT-B scale) and postoperative psychological status (Anxiety/Depression Self Rating Scale) assessments;
• Exclusion Criteria:
• • 1. Patients under 18 years old or over 70 years old;
• • 2. Those who have received breast cancer related surgery, radiotherapy or chemotherapy;
• • 3. Those who are not expected to receive surgery, radiotherapy or chemotherapy related to breast cancer
• • 4. History of other malignant tumors;
• • 5. Pregnant or lactating women;
• • 6. Accompanying active infection and fever;
• • 7. Other serious diseases that may significantly affect clinical trial compliance, such as severe cardiopulmonary dysfunction, liver and kidney dysfunction, poorly controlled diabetes and mental illness.