The Effect of Sequential Feeding for Circadian Rhythm and Gut Flora Rhythm in Critically Ill Patients

Launched by QINGDAO UNIVERSITY · Oct 9, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new way of feeding critically ill patients called "sequential feeding." Researchers believe that how we feed patients in the Intensive Care Unit (ICU) can help improve their health by aligning their feeding times with their body’s natural rhythms, known as circadian rhythms. These rhythms are important for maintaining a healthy metabolism and immune system. Previous studies showed that patients who received sequential feeding had better metabolic markers and changes in gut bacteria compared to those who were fed continuously.

To participate in this trial, patients must be newly admitted to the ICU and expected to stay for at least 10 days. However, those with diabetes, certain gastrointestinal diseases, or who can’t tolerate most of their nutritional needs through a feeding tube won’t be eligible. If enrolled, participants will receive either sequential feeding or continuous feeding, and the researchers will monitor their health and recovery throughout their stay. This trial aims to find out whether the new feeding method can improve health outcomes for critically ill patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients newly admitted to ICU were eligible for inclusion.
• Exclusion Criteria:
• • An estimated feeding time of less than 10 days in ICU;
• • Diabetes;
• • Gastrointestinal disease (gastrointestinal surgery, gastrointestinal bleeding, pancreatitis, Crohn's disease, ulcerative colitis, irritable bowel syndrome);
• • Inability to tolerate ≥80% of the nutrition target calories (25-30 kcal/kg/d) with enteral feeding through gastric tube;
• • The ability to eat orally at admission.