The Gastric HormonE BioMarkers of Preneoplastic Lesions Study

Launched by IMPERIAL COLLEGE LONDON · Oct 16, 2023

Keywords

ClinConnect Summary

The Gastric HormonE BioMarkers of Preneoplastic Lesions Study is a research trial aimed at understanding how certain hormones in the blood can indicate the health of the stomach lining. Researchers want to find out if levels of hormones like ghrelin, gastrin, pepsinogens, and vitamin B12 can show differences in people with healthy stomachs, those with mild inflammation (chronic atrophic gastritis), and individuals who have early changes that might lead to cancer (intestinal metaplasia). The trial will help doctors learn more about stomach health and potential risks for serious conditions.

To participate, you need to be an adult between 18 and 80 years old, able to read and understand English, and willing to give a blood sample. However, if you have been diagnosed with stomach cancer or have certain gastrointestinal conditions, like Crohn's disease, you won't be eligible. The study is not recruiting participants yet, but once it starts, people who meet the criteria will have the opportunity to contribute to important research that could improve understanding of stomach health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adult patients (18-80 years old) attending upper gastrointestinal endoscopy.
• • 2. Patients able to read and comprehend English.
• • 3. Patients willing and able to provide informed consent.
• • 4. Patients willing and able to provide a venous blood sample.
• Exclusion Criteria:
• • 1. Any individual diagnosed with gastric cancer, or with a history of gastric cancer, prior gastrectomy or bariatric surgery.
• • 2. Any individual with a chronic inflammatory condition of the gastrointestinal tract (Crohn's disease or ulcerative colitis).
• • 3. Once enrolment ceiling is reached for each group, enrolment will close for that group. The study will continue until all groups are complete.