Nebulization Versus Spray-as-You-Go Airway Topical Anesthesia Using Dexmedetomidine and Lidocaine Mixture During Awake Flexible Fiberoptic Intubation in Temporomandibular Ankylosis

Launched by TANTA UNIVERSITY · Oct 12, 2023

Keywords

ClinConnect Summary

This clinical trial is studying two different ways to numb the throat during a specific medical procedure called awake flexible fiberoptic intubation for patients with a condition known as temporomandibular ankylosis (TMJ ankylosis). The researchers want to find out whether using a nebulizer (a device that turns liquid medication into a mist) is more effective than a spray method for delivering a mixture of medications called dexmedetomidine and lidocaine. These medications help to make the throat numb to make the intubation process easier and more comfortable.

To participate in this study, individuals must be between 21 and 65 years old, have TMJ ankylosis, and are scheduled for surgery that requires general anesthesia. They should also be in good health according to specific medical guidelines. Participants can expect to receive one of the two methods of anesthesia during their procedure, and their comfort and the effectiveness of the anesthesia will be monitored. It's important to note that this trial is not for everyone; those with certain health conditions or allergies to the study medications cannot participate.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Age from 21to 65 years.
• • Both sexes.
• • American Society of Anesthesiologists (ASA) physical status I or II and scheduled for elective surgery requiring general anesthesia , and known to have Temporomandibular joint ankylosis and expected to be difficult intubation patient due to restriction of jaw mobility and limited mouth opening less than 2 fingers.
• Exclusion Criteria:
• • History of allergy to dexmedetomidine or lidocaine.
• • History of drug abuse.
• • Concomitant use of medications which may exaggerate the heart rate (HR) response of -dexmedetomidine (e.g. digoxin or β-adrenergic antagonists), HR \<50 beats/min, systolic blood pressure (SBP) \<90 mmHg.
• • Pregnancy.
• • Morbid obesity( BMI more than 35).
• • Patients on anticoagulants, nasal trauma, deformity or polyp, CSF rhinorrhea, fracture base skull.
• • Cardiac and/or respiratory disease, reactive airway disease, hepatic or renal disorders.