Don't Treat Ghosts Anti-MRSA Antibiotics in Osteomyelitis Without Identified MRSA

Launched by METHODIST HEALTH SYSTEM · Oct 17, 2023

Keywords

ClinConnect Summary

This clinical trial, titled "Don't Treat Ghosts Anti-MRSA Antibiotics in Osteomyelitis Without Identified MRSA," is studying how to better treat patients with osteomyelitis, which is an infection in the bones often caused by wounds or surgery. The trial aims to find out if using certain antibiotics that target a specific bacteria called MRSA (methicillin-resistant Staphylococcus aureus) is necessary when a patient does not have a confirmed MRSA infection. The researchers want to ensure that patients receive the most appropriate treatment without unnecessary use of these antibiotics.

To participate in this trial, individuals need to be at least 18 years old and have been admitted to a military hospital for osteomyelitis in the lower limb between April 2017 and April 2023. They should also have clear imaging results showing the infection and be planned for at least four weeks of treatment with intravenous antibiotics. Participants can expect close monitoring during their treatment, helping doctors understand the best way to manage this condition. This study is currently looking for volunteers, and your involvement could contribute valuable information to improve future care for osteomyelitis patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Admission to any MHS hospital between April 1, 2017 and April 1, 2023
• • \> 18 years of age
• • Documented osteomyelitis location of the lower limb via ICD-10 code
• • Documented imaging of lower limb osteomyelitis during index admission
• • Planned intravenous (IV) antibiotics for at least 4 weeks
• Exclusion Criteria:
• • • IV antibiotics for less than 24 hours inpatient
• • Planned surgical intervention documented at admission
• • Patients receiving monotherapy with an anti-MRSA agent
• • Positive MRSA culture during index admission
• • Current outpatient antibiotic use on index admission
• • Repeated hospital admission during study period