Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery

Launched by CEDARS-SINAI MEDICAL CENTER · Oct 19, 2023

Keywords

ClinConnect Summary

This clinical trial is studying two different combinations of medications used for anesthesia during spine surgery in teenagers with Adolescent Idiopathic Scoliosis. The goal is to find out which combination provides better pain control after the surgery. Participants will be randomly chosen to receive either Propofol and Remifentanil, which is commonly used at our hospital, or Propofol and Dexmedetomidine, which is more often used in adult surgeries. The researchers believe that using Dexmedetomidine may help reduce the need for extra pain medication after surgery, leading to less pain sensitivity.

To participate, you need to be between 12 and 18 years old and diagnosed with Adolescent Idiopathic Scoliosis, and you must be having a specific type of surgery called posterior spinal fusion. The study is currently recruiting participants, and those who join can expect to be monitored closely for pain levels and recovery times after the surgery. The findings from this trial may help improve pain management strategies for children undergoing spine surgery in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 12-18 years old
• • American Society of Anesthesiology Physical Status Classification (ASA Class) 1 and 2
• • Have diagnosis of Adolescent Idiopathic Scoliosis
• • Undergoing Posterior Spinal Fusion with instrumentation for scoliosis correction
• • Matched on age, sex, and the number of vertebral levels fused
• Exclusion Criteria:
• • Neuromuscular scoliosis
• • Allergy to any of the multi-modal analgesia regimen drugs
• • Use of serotonergic drugs, monoamine oxidase inhibitors (MAOI), mixed agonist/antagonist opioid analgesics