Hemolysis During Pulsed-field and Radiofrequency Ablation

Launched by CHARLES UNIVERSITY, CZECH REPUBLIC · Oct 20, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at the effects of two different types of heart procedures—radiofrequency ablation (RF) and pulsed-field ablation (PF)—on a condition called hemolysis, which is when red blood cells break down too quickly. The trial will involve patients who have atrial fibrillation (an irregular heartbeat) and are ready for catheter ablation. Researchers will take blood samples from participants at different times during and after the procedure to see how each method affects hemolysis. The main question is whether hemolysis occurs more after pulsed-field ablation compared to radiofrequency ablation.

To be eligible for this trial, participants should be between the ages of 18 and 75 and have symptomatic atrial fibrillation that requires treatment with catheter ablation. They must be willing to take part in the study. However, some individuals won't be able to join, such as those who are pregnant, have certain blood disorders, or have other health issues related to hemolysis. Participants can expect to undergo the standard ablation procedure and have their blood tested at specific times to help researchers gather important data. This study is important as it aims to improve our understanding of how different ablation techniques affect patients' health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • symptomatic atrial fibrillation indicated for catheter ablation
• • willingness to participate
• Exclusion Criteria:
• • pregnancy
• • any known malignant or non-malignant hematological disorder
• • malignancy
• • age \> 75 years
• • any disease associated with hemolysis
• • hemoglobin concentration less than 100 g/L
• • liver cirrhosis