The Effects of Zinc Di-(Dibutyryl Lisinate) on Skin Health and the Skin Microbiome in Photoaged Skin

Launched by INTEGRATIVE SKIN SCIENCE AND RESEARCH · Oct 17, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how a new product called Zinc Di-(dibutyryl lisinate) (often shortened to Z-DBL) affects skin health, especially for women who have signs of aging on their skin, like fine lines and wrinkles. The study will measure things like skin hydration (how moist the skin is), how well the skin retains water, and its elasticity (how stretchy it is). Researchers are also interested in how this product may change the balance of microorganisms on the skin, known as the skin microbiome, which can influence skin health.

To participate in this study, you need to be a woman aged 40 to 60 who has visible signs of photoaging, which means your skin has aged due to sun exposure. Participants will be asked to limit their time in the sun and refrain from certain skin treatments or products during the study. If you join, you will receive Z-DBL or a similar product (a "vehicle") without knowing which one you have, as the study is double-blind. This means neither you nor the researchers will know to ensure unbiased results. The trial is not currently recruiting, so you'll need to keep an eye out for when it starts.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Females between the ages of 40 years of age until 60 years of age
• • Participants must have facial fine lines and wrinkles
• • Subjects must minimize sun exposure
• • Subjects must avoid professional or facial spa procedures during the study
• Exclusion Criteria:
• • Individuals who are pregnant or breastfeeding.
• • Prisoners.
• • Adults unable to consent.
• • Those who are unwilling to discontinue topical hydroquinone, retinoids, bakuchiol, vitamin C, or acetyl zingerone containing products for two weeks to meet the washout criteria prior to enrolling.
• • Those who are unwilling to discontinue topical antibiotics and benzoyl peroxide for two weeks to meet the washout criteria prior to enrolling.
• • Those who have been on an oral antibiotic within 1 month prior to enrolling.
• • Subjects with any of the following facial cosmetic treatments in the past 3 months or those who are unwilling to withhold the following facial cosmetic treatments during the study including botulinum toxin, injectable fillers, microdermabrasion, intense pulsed light (IPL), peels, laser treatments, acid treatments, facial plastic surgery, or any other medical treatment administered by a physician or skin care professional which is designed to improve the appearance of facial skin.
• • Those who are unwilling to discontinue all facial topical products except the product provided in the study.
• • Individuals who have changed any of their hormonal based contraception within 3. months prior to joining the study.
• • Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years.