Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension

Launched by MEDICAL UNIVERSITY OF VIENNA · Oct 19, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how changes in blood pressure affect the tiny blood vessels in the eye of patients with high blood pressure, also known as arterial hypertension. The researchers want to find out if there are any lasting differences in the eye's structure and function after these patients have successfully lowered their blood pressure through medication.

To be eligible to participate, you must be at least 18 years old, be a non-smoker, and have mild to moderate high blood pressure. You should also be ready to take new blood pressure medication and keep track of your readings in a diary. Participants can expect to undergo regular eye examinations and will be closely monitored for changes in their blood vessels as their blood pressure improves. It's important to note that some people, such as those with certain medical conditions or those who are pregnant, may not qualify for this study.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Men and Women aged ≥ 18 years
• • Signed informed consent
• • Apart from hypertensive retinopathy, normal ophthalmic findings
• • Non-Smokers
• • Patients with initially diagnosed or pre-existing mild to moderate primary arterial hypertension (systolic office blood pressure ≥ 140 mmHg and/or diastolic office blood pressure ≥ 90 mmHg)
• • Planned initiation of antihypertensive medication or planned adaption of antihypertensive medication by the Department of Cardiology
• • Subject agrees to perform regular blood pressure self-measurements and to document blood pressure values in a diary
• Exclusion Criteria:
• • Participation in a clinical trial in the three weeks preceding the study
• • Blood donation in the three weeks preceding the study
• • Symptoms of a clinically relevant illness in the three weeks preceding the study
• • History of family history of epilepsy
• • Secondary hypertension (e.g.: hyperaldosteronism, pheochromocytoma, renal artery stenosis, renal parenchymal diseases, Cushing-syndrome, Coarctatio aortae)
• • History of hypertensive encephalopathy or intracerebral bleeding
• • Diabetes mellitus Type 1 or Type 2
• • Pregnant or breast-feeding women
• • Women of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception