Effect of Physical Activity on Neurogenesis in Peripheral Diabetic Neuropathy Type-II Diabetes

Launched by HEALTH EDUCATION RESEARCH FOUNDATION (HERF) · Oct 20, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how physical activity can help improve nerve growth in people with Type II Diabetes who experience nerve damage, known as peripheral diabetic neuropathy. Researchers aim to see if exercise can enhance both nerve health and blood sugar control, which are important for improving the quality of life for patients. The study will include participants aged 16 to 21 who have specific symptoms related to nerve damage, such as numbness, tingling, or pain in their feet, and who can engage in at least 20 minutes of physical activity each week.

To be eligible, participants need to have a certain level of nerve damage, as measured by a scale, and their blood sugar levels should be above a specific threshold. However, individuals with certain health issues, like severe vision problems, significant heart issues, or those who can't exercise without help, will not be included. Those who join the study can expect to engage in physical activity and may benefit from improved nerve function and overall well-being. This research is important because it can help us understand how exercise might be used as a treatment for managing diabetic neuropathy and improving patients' lives.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with Type-II Peripheral Diabetic Neuropathy
• • Neuropathy Total Symptom Scale (NTSS-6)\>6
• • loss of protective sensation to detect a 10-gram Semmes Weinstein Monofilament on either foot at one of four sites tested or a vibration perception threshold value of 25V or more at either foot's hallux
• • Numbness or reduced ability to feel pain or temperature changes.
• • Able to Perform 20 minutes per week \>2 bouts of physical activity
• • Tingling or burning sensation.
• • Sharp pains or cramps.
• • Increased sensitivity to touch
• • Symptoms last ≥ 6 months
• • HbA1c above 6.5% \<12%
• • Berg Balance Scale score 45-56
• Exclusion Criteria:
• • Patients with walking difficulty
• • Retinopathy \& poor vision
• • Inability to engage in activity without assistance
• • Peripheral vascular disease e.g. ABI \<0.6
• • orthostatic hypotension, resting heart rate above 100 bpm any Cardiac Issues
• • Any diagnosed neuro-psychological issue e.g. depression, dementia or anxiety
• • Lower limb amputation,foot deformity or ulceration
• • Acute injury
• • Hip and Knee OA