Effect of Vitamin D Supplementation on Allostatic Load and Chronic Stress Along Line of Control in Azad Jammu Kashmir

Launched by UNIVERSITY OF THE PUNJAB · Oct 24, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how high doses of vitamin D might affect stress and overall health in people living near the line of control in Azad Jammu and Kashmir. Researchers want to find out if taking vitamin D can lower chronic stress and improve health indicators like blood pressure and body weight. The study will involve 120 participants between the ages of 18 and 60 who have lived in the Haveli district for at least a year and have experienced stress related to conflict.

Participants will receive either vitamin D supplements or a placebo (a dummy pill) for one year, and neither the participants nor the researchers will know who receives what to ensure fairness in the results. The trial is not yet recruiting, but if you meet the criteria and are interested, you could help us learn more about the potential benefits of vitamin D for managing stress and improving health. It's important to note that some individuals, such as pregnant women or those with certain medical conditions, will not be eligible to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 18 and 60 years.
• • 2. Resident of District Haveli, Azad Kashmir for more than last 1 year.
• • 3. Consent to participate in the study.
• • 4. Exposure to war-related stressors (self-reported).
• Exclusion Criteria:
• • 1. Age below 18 or above 60 years
• • 2. Ingestion of vit D 200,000 IU in last 3 months.
• • 3. Known diagnosis of primary hyperparathyroidism or sarcoidosis (i.e. conditions pre-disposing to vitamin D hypersensitivity)
• • 4. Residents outside of District Haveli.
• • 5. Baseline corrected serum calcium concentration \>2.65 mmol/L
• • 6. Unwillingness to provide informed consent.
• • 7. Medical conditions or medication use affecting vitamin D metabolism.
• • 8. Pregnant or lactating mothers
• • 9. On anti-tuberculosis medicines
• • 10. HIV infection