Quantitative Perfusion Imaging Using Contrast Enhanced Perfusion Ultrasound, MRI and Perfusion Angiography

Launched by UNIVERSITY COLLEGE, LONDON · Oct 24, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring new imaging techniques to better understand blood flow in the legs and feet, particularly for those with Peripheral Arterial Disease (PAD). PAD is a common condition where blood vessels that supply the legs become narrowed or blocked, which can lead to serious problems like pain, ulcers, and even amputations. The researchers aim to use advanced ultrasound and MRI scans to measure blood circulation in the tissues, helping doctors diagnose PAD earlier and treat it more effectively.

To participate in this study, you need to be at least 40 years old and able to give informed consent. Both healthy individuals and those diagnosed with PAD are eligible to join. Over a two-year period at University College London and the Royal Free Hospital, participants will receive an ultrasound scan with a special dye injection and an MRI scan. This trial runs alongside standard care for PAD, meaning you'll still receive regular treatment while contributing to valuable research that could improve care for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Disease-free participants:
• • 1. Adult patients older than 40 years old
• • 2. Subjects able to and willing to give informed consent
• • 3. Staff from University College London Hospital/University College London
• Participants with Peripheral Arterial Disease :
• • 1. Patients able to and willing to give informed consent
• • 2. Peripheral Arterial Disease Rutherford Classification stages 1- 6
• • 3. Patients referred by University College London Hospital or Royal Free Hospital.
• • Exclusion Criteria
• Disease-free participants:
• • 1. Prior history of Peripheral Arterial Disease
• • 2. History of diabetes, tobacco smoking or cardiovascular, vasculitides or muscle disease
• • 3. Any contraindication to magnetic resonance imaging or contrast enhanced ultrasound- metal implants not compatible with magnetic resonance imaging; documented allergy to SonoVue; patients with right-to-left shunts assessed with transthoracic echocardiogram, severe pulmonary hypertension (pulmonary artery pressure \>90 mmHg), uncontrolled systemic hypertension, and in patients with adult respiratory distress syndrome and recent myocardial infarction/ acute coronary syndrome in the preceding 7 days.
• • 4. Participants not from University College London Hospital/University College London
• Peripheral Arterial Disease participants:
• • 1. Concurrent and/or recent involvement in other research that is likely to interfere with the intervention within 3 months of study enrolment
• • 2. Any contraindication to magnetic resonance imaging or contrast enhanced ultrasound - metal implants not compatible with magnetic resonance imaging; documented allergy to SonoVue; patients with right-to-left shunts assessed with transthoracic echocardiogram, severe pulmonary hypertension (pulmonary artery pressure \>90 mmHg), uncontrolled systemic hypertension, and in patients with adult respiratory distress syndrome and recent myocardial infarction/ acute coronary syndrome in the preceding 7 days.
• • 3. Patients outside University College London Hospital or Royal Free Hospital.