Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis

Launched by UNIVERSITY OF TEXAS, EL PASO · Oct 23, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how different types of exercise can affect knee pain and the way our bodies process pain in people with knee osteoarthritis. Specifically, researchers want to see if exercising the arms or the legs can help reduce pain and improve overall function. They will also look at how factors like socioeconomic status and experiences of discrimination might influence how effective the exercises are. The study will involve 40 participants with knee osteoarthritis and will take place over three days, where each person will try both types of exercises.

To be eligible for the study, participants should be at least 45 years old, have knee pain that affects their daily activities, and meet other specific health criteria. Those with certain medical conditions, such as severe pain issues or a history of knee surgery, will not be able to participate. If you join, you can expect to complete some assessments on the first day, followed by exercise sessions on the next two days. This trial aims to help improve understanding of how exercise can relieve pain in people with knee osteoarthritis.

Gender

ALL

Eligibility criteria

• • Participants with knee OA (Target n=40)
• Inclusion Criteria:
• We will recruit participants with knee OA, using the National Institute for Health and Care Excellence's clinical diagnostic criteria, which does not require radiographs. The clinical diagnostic criteria include:
• • age ≥45
• • activity-related knee pain
• • either no morning joint-related stiffness or stiffness that lasts ≤ 30 minutes.
• • knee pain at least 4 on a 0-10 pain scale
• • knee pain as a chief complaint if having multiple pain
• • understand English
• Exclusion Criteria:
• • peripheral neuropathy or other sensation loss on the body sites for pain measurements (i.e., the wrist, knee, the forearm)
• • use of medical devices electrically active (e.g., pacemaker)
• • chronic use of opioids
• • pregnant women
• • serious and uncontrolled concomitant disease, including cardiovascular, nervous system, pulmonary, renal, hepatic, metabolic, hormonal, endocrine, gastrointestinal or epileptic disease
• • rheumatoid arthritis, ankylosing spondylitis, and any neurological disorders that prevent the study procedure
• • cognitive impairment
• • history of a knee replacement surgery
• • inability to perform exercise due to severe pain or other symptoms
• • any intervention procedures for knee pain in the last 3 months
• • Inclusion and exclusion criteria for pain-free controls (Target n = 20) Pain-free controls are not having a pain-related medical condition. They have to speak and understand English. Pain-free controls are excluded if they had experienced a pain episode, caused by musculoskeletal injury or otherwise in the previous 3 months.