Reducing Overuse of Antibiotics at Discharge Home
Launched by UNIVERSITY OF UTAH · Oct 23, 2023
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
The Reducing Overuse of Antibiotics at Discharge (ROAD) Home study is designed to test the hypothesis that hospitals randomized to an implementation intervention that includes external facilitation to support participants while allowing for free choice in selecting and implementing evidence-based antibiotic stewardship strategies based on local context will have fewer days of antibiotic overuse at discharge than "stewardship as usual" control hospitals. The first aim of this study is to evaluate the effectiveness of the ROAD Home Intervention on days of antibiotic overuse at discharge for h...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- All Patients:
- • Adult patient admitted and discharged from the participating hospital and included in HMS registry
- • Admitted to a general care medicine service
- • Received any eligible antibiotic during the symptom collection window (-1 to +2 days for UTI; day 1 or 2 for pneumonia)
- • Immunocompetent (allowing for mild immune suppression)
- • Do not have a concomitant infection (e.g., antibiotic treatment for unrelated infection or prophylaxis)
- Specific inclusion criteria for patients with UTI:
- • Positive urine culture
- • Have normal urinary anatomy
- Specific inclusion criteria for patients with pneumonia:
- • - Discharge diagnosis of pneumonia
- Exclusion Criteria:
- All Patients:
- • Left against medical advice or refused medical care
- • Admitted on hospice
- • Pregnant
- • Unable to determine actual or expected antibiotic duration
- Specific exclusions for patients with UTI:
- • - spinal cord injury
- Specific exclusions for patients with pneumonia:
- • Cystic fibrosis
- • Pneumonia-related complication (e.g., empyema)
About University Of Utah
The University of Utah is a prestigious research institution known for its commitment to advancing medical knowledge and improving patient care through innovative clinical trials. With a robust infrastructure that supports a wide range of biomedical research initiatives, the university leverages its multidisciplinary expertise and state-of-the-art facilities to conduct rigorous clinical studies. By fostering collaboration among researchers, clinicians, and community partners, the University of Utah aims to translate scientific discoveries into effective therapies and interventions, ultimately enhancing health outcomes and contributing to the advancement of medical science.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Salt Lake City, Utah, United States
Patients applied
Trial Officials
Valerie M Vaughn, MD
Principal Investigator
University of Utah
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported