Clinical Feasibility of Brain Radiotherapy Using Synthetic CTs in an MRI-only Workflow

Launched by UNIVERSITY OF ERLANGEN-NÜRNBERG MEDICAL SCHOOL · Oct 24, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to plan radiotherapy (a type of treatment that uses high-energy rays to kill cancer cells) for patients with brain tumors. The researchers want to see if using MRI scans alone, combined with advanced computer technology to create synthetic CT images, can be a practical option for treating brain tumors. This method could simplify the process and improve treatment planning by avoiding the need for traditional CT scans, which are usually part of the routine.

To participate in this study, individuals must be at least 18 years old and have a brain tumor or metastatic cancer that has spread to the brain. They also need to be able to stay still during treatment, which is done using a special mask. However, some people may not qualify, such as those with metal implants, certain health issues, or those who are pregnant or breastfeeding. If eligible, participants can expect to receive treatment similar to standard care, and the study will evaluate how well this new approach works compared to traditional methods. It's important to note that the trial is not yet recruiting participants, but it aims to gather valuable information about the feasibility of this MRI-only approach in brain radiotherapy.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Written informed consent
• • Patient older than 18 years
• • Tumor or metastases in the brain
• • Immobilization with stereotactic mask
• • Treatment on stereotactic linear accelerator (2.5 mm leafs) equipped with 2D/2D X-ray system
• Exclusion Criteria:
• • Metal in the body, metal implants, pacemakers or other patient-specific factors that are a contraindication to an MRI scan
• • Metal implants, pacemakers or other patient-specific factors associated with increased risk from an MRI scan
• • Renal insufficiency (eGFR \< 60 ml/min), allergy or other patient-specific factors that constitute a contraindication to contrast administration
• • Renal insufficiency (eGFR \< 60 ml/min), allergy or other patient-specific factors associated with an increased risk from contrast administration
• • Patients who are institutionalized in care facilities, prisons or other supervised facilities.
• • Patients under guardianship
• • Non-consenting patients
• • Pregnant or breastfeeding patients