Maimonides Minocycline in Stroke Study

Launched by MAIMONIDES MEDICAL CENTER · Oct 25, 2023

Keywords

ClinConnect Summary

The Maimonides Minocycline in Stroke Study is a clinical trial designed to see if a medication called Minocycline can help improve outcomes for patients who have just had a stroke. The trial will compare two groups of participants: one group will receive Minocycline along with standard stroke care, while the other group will only receive the usual care. The study aims to find out if taking Minocycline can lead to better recovery and lower chances of death after a stroke.

To participate, individuals must be at least 18 years old and have symptoms of a stroke that started within the last 24 hours. They should have measurable neurological problems, which means they may have difficulty speaking, moving, or understanding things. Participants will take the medication for five days, and their health will be monitored at various times, including during their hospital stay and again after they go home. This trial is currently recruiting participants, and it's important to note that individuals with certain health conditions, allergies to Minocycline, or those who are pregnant may not be eligible to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age \>/=18
• • 2. Acute onset neurological deficit consistent with acute ischemic stroke or on imaging consistent with acute ischemia as defined by WHO (World Health Organization) guidelines
• • 3. Acute onset of neurological deficits with intracerebral Hemorrhage on imaging consistent with intracerebral bleed
• • 4. The onset of symptoms less than 24 hours
• • 5. Measurable neurological deficit using NIHSS (National Institutes of Health Stroke Scale )
• Exclusion Criteria:
• • 1. Clinically not suspect stroke.
• • 2. Allergic to the Tetracycline group of medications or Intolerance to Minocycline
• • 3. Pregnancy or suspected pregnancy
• • 4. Previous history of intolerance to minocycline
• • 5. Acute or chronic renal failure
• • 6. Any patients with contraindications to undergo CT/ MRI
• • 7. Life expectancy less than one year or severe co-morbidities or comfort measure only (CMO) on admission
• • 8. Pre-existing infectious disease requiring antibiotics
• • 9. Inability to tolerate enteral medications/feeds
• • 10. Patient/ family refusal