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Search / Trial NCT06107842

Gerofit and Cognition

Launched by VA OFFICE OF RESEARCH AND DEVELOPMENT · Oct 25, 2023

Trial Information

Current as of July 22, 2025

Recruiting

Keywords

ClinConnect Summary

The "Gerofit and Cognition" trial is studying how exercise can help improve thinking and memory in older Veterans, especially those 65 years and older who might have issues like PTSD or depression. Many older Veterans are at a higher risk for cognitive problems, but there hasn't been enough research on how physical activity can benefit their brain health. This trial aims to see if joining the VA Gerofit exercise program can enhance mental function and if certain blood and muscle tests can predict these improvements.

To participate, Veterans must be at least 65 years old and get approval from their primary care doctor to join the Gerofit program. However, those who struggle with daily activities, have serious cognitive issues, or cannot move independently may not qualify. If eligible, participants can expect to engage in exercise activities designed to boost both physical and mental health, potentially leading to a better quality of life. It's important to note that the trial also seeks to understand how different health factors can influence the benefits of exercise on thinking skills in older Veterans.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • All Veterans eligible for VA Gerofit program 65 years and older
  • Clearance by PCP to participate in Gerofit exercise program
  • Exclusion Criteria:
  • Inability to perform ADLs
  • Significant cognitive impairment
  • Inability to function independently without assistance
  • Unstable angina; proliferative diabetic retinopathy
  • Oxygen dependent
  • Unwillingly to commute and/or not able to provide own transportation to Gerofit
  • Incontinence
  • Open wounds
  • Volatile behavioral issue or unable to work successfully in a group environment/setting
  • Active substance abuse
  • Homelessness

About Va Office Of Research And Development

The VA Office of Research and Development (ORD) is dedicated to advancing the health and well-being of veterans through innovative research initiatives. As a pivotal sponsor of clinical trials, ORD focuses on a broad spectrum of health-related topics, including mental health, rehabilitation, and chronic disease management, ensuring that findings are directly applicable to the unique needs of the veteran population. With a commitment to scientific excellence and collaboration, ORD promotes rigorous study designs and ethical standards, facilitating the translation of research discoveries into improved clinical practices and policies that enhance veteran care.

Locations

Baltimore, Maryland, United States

West Los Angeles, California, United States

Patients applied

0 patients applied

Trial Officials

Cathy C Lee, MD

Principal Investigator

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Jonathan M Wanagat, MD PhD

Principal Investigator

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Stacy Wilkins, PhD

Principal Investigator

VA Greater Los Angeles Healthcare System, West Los Angeles, CA

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported