Using Electrical Impedance Tomography to Investigate the Relationship Between Airflow Rate During High-flow Oxygen Therapy and Pressure in Patients With Heart Failure Compared to Non-invasive Ventilation

Launched by NATIONAL TAIWAN UNIVERSITY HOSPITAL · Oct 26, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how two different treatments—High-Flow Oxygen Therapy (HFOT) and Non-Invasive Ventilation (NIV)—affect patients with heart failure. The main goal is to see how the airflow rate during HFOT relates to pressure in the lungs, which could help improve how these therapies are used for breathing support. The study will involve patients in the intensive care unit who are stable and have specific lung issues, such as pulmonary infiltrates on a chest X-ray. Eligible participants must be alert and able to follow instructions.

If you or a loved one joins the trial, you will experience both HFOT and NIV treatments in a specific order over about 1 to 1.5 hours. Your vital signs and breathing patterns will be closely monitored using a special device called Electrical Impedance Tomography (EIT). Participants will be positioned comfortably while the treatments are given, and all data collected will be analyzed later. This study aims to provide more clarity on how these therapies work together, potentially leading to better care for heart failure patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients in the intensive care unit (ICU) with PaO2/FiO2 ≤ 300, requiring Non-Invasive Ventilation (NIV) and High-Flow Oxygen Therapy (HFOT) and stable use of NIV and HFOT for at least 24 hours will be eligible for enrollment.
• • Evidence of pulmonary infiltrates on chest X-ray in patients with heart failure.
• • Alert and able to follow instructions.
• Exclusion Criteria:
• • Age \< 18 years.
• • Patients with a history of tracheostomy.
• • Hemodynamically unstable (defined as a mean arterial pressure persistently below 60 mmHg despite fluid resuscitation or vasopressor support).
• • Severe chronic obstructive pulmonary disease (COPD).
• • History of nasal trauma and/or nasal septal deviation or any other reason preventing the use of High-Flow Oxygen Therapy (HFOT).
• • Presence of facial wounds or any other reason preventing the use of Non-Invasive Ventilation (NIV).
• • Contraindications to Electrical Impedance Tomography (EIT) use (e.g., patients with implanted pacemakers) or inability to place EIT belt (e.g., due to wound dressings or chest drainage).