Impact of Negative Pressure Ventilation in Patients Hospitalized with Acute Hypercapnic Respiratory Failure

Launched by UNIVERSITY OF MISSOURI-COLUMBIA · Oct 30, 2023

Keywords

ClinConnect Summary

This clinical trial is looking to see if a special type of breathing support called Biphasic Cuirass Ventilation works as well as another method known as Non-invasive Positive Pressure Ventilation for patients who are hospitalized with a serious breathing problem known as acute hypercapnic respiratory failure. This condition happens when there is too much carbon dioxide in the blood, making it hard to breathe properly. The trial is currently recruiting participants, and anyone aged 21 or older who has been diagnosed with this condition may be eligible, as long as they meet specific health criteria.

Participants in this study can expect to compare the two breathing support methods during their hospital stay. It’s important to note that some people cannot take part in the trial, including those who are pregnant, under 21, or have certain medical conditions that would make using the Biphasic Cuirass Ventilation unsafe. Overall, this study aims to find the best way to help patients breathe easier when dealing with this serious health issue.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • admission diagnosis of hypercapnic respiratory failure
• • pH between 7.20-7.35 in an ABG sample or pH between 7.16-.31 in a venous sample.
• Exclusion Criteria:
• • age \<21
• • Pregnant
• • Inmate/Prisoner
• • Contraindication for cuirass ventilator (open chest wound, flail chest, prior thoracic surgery)
• • Chest wall defect, neuromuscular disease or diaphragmatic paralysis.
• • BMI \>50