Clearance of Vasoactive Metabolites With Blood Purification

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Oct 27, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at a treatment called extracorporeal blood purification for critically ill patients who are experiencing a condition known as vasoplegic shock, often related to severe infections like sepsis. The goal is to see if using a special blood filter, called oXiris, can help improve blood flow and overall health by removing certain substances in the blood that may be contributing to the patient's condition. Previous studies have shown promising results, suggesting that patients treated with this filter may show significant improvement in their need for medications to support blood pressure within just 24 hours.

To participate in this trial, patients must be admitted to the intensive care unit with vasoplegic shock and be at least 6 years old and weighing 30 kg (about 66 pounds). The healthcare team must believe that blood purification is necessary for their treatment. It’s important to note that patients who do not need this type of treatment or have certain other conditions may not be eligible. Participants in the trial can expect to receive standard care along with the blood purification treatment, and the research team will monitor their progress closely to assess the effectiveness of the therapy.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients admitted to intensive care with vasoplegic shock (hemodynamic support by noradrenaline).
• • Adult or child ≥ 6 years and 30kg
• • Indication for extrarenal purification for acute, chronic renal failure, oliguric hydrosodic overload, refractory metabolic acidosis or severe hydroelectrolyte disorder
• • Clinician's decision to use an oXiris hemofilter with blood purification capability
• • For adult patients: no opposition from the patient (or person of trust or close friend if the patient is unable to be informed)
• • For minor patients: no opposition of the holders of parental authority
• Exclusion Criteria:
• • No need for hemofiltration.
• • Citrate anticoagulation of the hemofiltration circuit
• • Inclusion in a category 1 or 2 interventional study protocol. Patients included in category 3 interventional research will be able to participate in the study after assessment by the physician.
• • Patient under judicial protection and adults under guardianship or curatorship.
• • Patient with no social security affiliation