The Efficacy and Safety of LMV-12 Combined With Osimertinib in NSCLC

Launched by HUNAN PROVINCE TUMOR HOSPITAL · Oct 25, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at the safety and effectiveness of a new treatment called LMV-12, which is being tested in combination with another medication called osimertinib for patients with advanced non-small cell lung cancer (NSCLC). The trial is open to adults aged 18 and older who have a specific type of NSCLC that has not responded to previous treatments. To participate, patients must have a confirmed diagnosis of advanced NSCLC, and they should have specific genetic markers like a RET gene mutation or MET amplification.

Participants in the trial can expect to receive the combination treatment and will be monitored closely for any side effects and how well the treatment works. It’s important to note that this study is currently recruiting, so eligible patients can join. However, there are certain criteria that must be met, such as being in good overall health and not having certain medical conditions or previous treatments that could interfere with the study. All participants will need to provide informed consent and agree to follow specific guidelines throughout the trial.

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Eligibility criteria

• Inclusion Criteria:
• * Eligible subjects selected for this study must meet all of the following criteria:
• • 1. Sign written informed consent before implementing any trial-related procedures;
• • 2. Age ≥18 years old;
• • 3. No limit on the gender;
• • 4. Histological or cytological confirmed advanced or metastatic non-small cell lung cancer, ineligible for radical surgery, relapse after failure of previous treatment with first-line (including first, second, and third generation)EGFR inhibitors.
• • Cohort A：MET amplification,(by FISH, NGS or IHC) Cohort B：RET fusion.
• 5. Laboratory tests for organ function levels must meet the following requirements:
• • 1. Absolute neutrophil count ≥ 1.5 × 109/L;
• • 2. Platelet count ≥ 100 × 109/L;
• • 3. Hemoglobin ≥ 9 g/dL;
• • 4. Bilirubin ≤1.5 times ULN; e) AST and ALT ≤2.5 times ULN (total bilirubin ≤3 times the upper limit of normal and AST and ALT ≤5 times the upper limit of normal are permitted if hepatic metastases are present);
• • f) Serum creatinine ≤ 1.5 times ULN or creatinine clearance ≥ 60 mL/min (according to the Cockcroft-Gault formula);
• • 6. For premenopausal women of childbearing potential a pregnancy test must be performed within 7 days prior to initiation of treatment, a serum pregnancy test must be negative, and they must be non-lactating; all enrolled patients (whether male or female) should use adequate barrier contraception throughout the treatment period and for 3 months after completion of treatment.
• Exclusion Criteria:
• • 1. Subjects treated with CYP isozyme inducers or inhibitors (see Appendix 4 for details) within 3 weeks prior to enrollment;
• • 2. Pregnant or lactating women;
• • 3. History of immunodeficiency or other acquired, congenital immunodeficiency diseases;
• • 4. Patients with prior bone marrow transplantation or prior solid organ transplantation;
• • 5. Patients with a combination of gastrointestinal perforation, gastrointestinal fistula, or non-gastrointestinal fistula;
• • 6. Prior history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis requiring steroid therapy, or any evidence of clinically active interstitial lung disease.
• • 7. Hepatitis B, hepatitis C, or human immunodeficiency virus (HIV-positive). Hepatitis B is eligible for this study at \<500 IU/mL (or 2500 cps/mL) by quantitative HBV-DNA testing, and hepatitis C (HCV) antibody-positive patients are eligible for this study only if the polymerase chain reaction shows HCV RNA negativity;
• • 8. Fulfillment of any of the following cardiac criteria: (i) Bazetts' mean corrected QT interval (QTc) derived from electrocardiogram (ECG) examination at rest \>470 msec (women) or \>450 msec (men) (in the case of the 1st abnormality, retested once within 48 h and calculated by averaging the results of the 2 times); and (ii) a wide variety of clinically significant rhythmic, conduction, and resting ECG morphologic Abnormalities, such as complete left bundle branch block, grade III conduction block, grade II conduction block, PR interval \>250 msec; (iii) Myocardial ischemia or myocardial infarction of grade I or higher, or congestive heart failure of grade ≥2 (New York Heart Association (NYHA) classification); (iv) Factors that may increase the risk of prolongation of QTc or the risk of arrhythmic events, such as coronary artery disease, heart failure hypokalemia, congenital long QT syndrome, family history of a first-degree relative with long QT syndrome or sudden unexplained death before the age of 40, and ongoing use of any medication known to prolong the QT interval;