Evaluation of the Safety and Efficacy of Hemophilia A Gene Therapy Drugs

Launched by SHANGHAI BELIEF-DELIVERY BIOMED CO., LTD · Oct 31, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for Hemophilia A, a condition where the blood does not clot properly. The treatment being tested is called BBM-H803, which is a one-time injection designed to help increase the levels of a protein called factor VIII in the blood. This protein is essential for blood clotting, and the trial aims to see how safe and effective this treatment is for men with severe Hemophilia A.

To be eligible for the trial, participants need to be males aged 18 or older who have been diagnosed with severe Hemophilia A and meet certain health criteria, such as not having a history of serious allergic reactions to previous treatments. During the study, participants will receive the injection and then be monitored for any side effects and improvements in their condition. It’s important for potential participants to know that they should not have any significant liver problems or ongoing infections, and they need to follow the study rules to ensure their safety throughout the trial.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Subjects voluntarily sign informed consent form;
• • 2. Males ≥ 18 years;
• • 3. Subjects are clinically diagnosed with severe hemophilia A;
• • 4. Have \> = 150 documented exposure days to a Factor VIII protein product
• • 5. No prior history of hypersensitivity or anaphylaxis associated with any FVIII immunoglobulin;
• • 6. Use a reliable contraception method during the study;
• • 7. Capsid antibody negative;
• • 8. Subjects have good compliance.
• Exclusion Criteria:
• • 1. Being positive for hepatitis B surface antigen (HBsAg) or hepatitis B virus-DNA (HBV-DNA). Being positive for hepatitis C virus antibody (HCV-Ab) or hepatitis C virus RNA (HCV-RNA).
• • Subjects with medical history of hepatitis B or C can be regarded as negative only when 2 required samplings are conducted at least 3 months apart and both test results of indicators aforementioned are negative, HIV positive patients or Syphilis seropositive patients;
• • 2. Currently on antiviral therapy for hepatitis B or C;
• • 3. Suffer from coagulation disorders other than hemophilia A;
• • 4. In addition to glucocorticoids, any other immunosuppressants are being used before selection;
• • 5. Have vaccination history within 2 months before administration, or vaccination schedule during immunomodulatory therapy;
• • 6. Have potential liver diseases, such as previous diagnosis of portal hypertension, splenomegaly, hepatic encephalopathy or liver fibrosis (fibrosis stage ≥ 3); nodules or cysts were found by B ultrasound, or elevated alpha-fetoprotein was detected by laboratory tests. Subjects who are not eligible for the study if the abnormalities are clinically significant regarding to the medical judgement of the investigator;
• • 7. Scheduling of elective major surgery known or planned during the insertion period or the 52-week study period following BBM-H803 infusion;
• • 8. Have participated in a previous gene therapy research trial before screening or have used other test drugs within 4 weeks before screening, or within 5 half-life of the test drug, whichever is longer; Have received emesezumab within 6 months before screening; Or drugs evaluated by the researcher to affect the study;
• • 9. Any herbal preparations (herbal supplements or traditional Chinese medicines of plant, mineral or animal origin) used during the 4 weeks prior to or during the study that may affect liver function, except topical use; Or any Chinese herbal medicine that the researcher evaluates to affect the study;
• • 10. Have alcohol or drug addiction, or cannot stop drinking as advised by the researcher throughout the study;
• • 11. Have acute/chronic infections or other chronic diseases that may pose a risk for the study, or have a major illness, who have a current or previous history of malignant tumors, or who have other unstable medical conditions, including poor mental state and risk of suicide, that the investigator deems unsuitable for participation in the study;
• • 12. Any other conditions that the investigator deems unsuitable for participation in the study.