Non-invasive Coronary Thrombus Imaging to Define These Cause of Acute Myocardial Infarction

Launched by UNIVERSITY OF EDINBURGH · Oct 27, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a new imaging test that can help doctors see if there is a blood clot in the heart arteries of patients who have recently had a heart attack. While current blood tests can tell if there has been damage to the heart, they often don’t reveal what caused the heart attack. By using this advanced imaging technique, researchers hope to provide better diagnoses and ensure patients receive the right treatment, ultimately improving their health outcomes.

The study is looking for 80 adults aged 18 and older who have experienced chest pain and have certain test results indicating a heart attack. Participants will undergo several tests, including a special heart scan called a PET-CT, an ultrasound, and an MRI, along with a blood test. They will also complete a follow-up questionnaire 6 to 12 months after their heart attack. It’s important to note that some individuals may not be eligible if they have specific heart conditions or other health issues. This trial could lead to significant improvements in how heart attacks are diagnosed and treated.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Males and females ≥ 18 years of age
• • Clinical presentation of chest pain, ST-segment deviation within a coronary artery territory on the electrocardiogram, raised cardiac troponin and non-obstructive coronary arteries on invasive coronary angiography as per international societal diagnostic criteria
• Exclusion Criteria:
• • \<18 years of age
• • Takatsubo cardiomyopathy
• • Myocarditis
• • Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2)
• • Woman of child-bearing potential who are pregnant or breastfeeding
• • Known allergy or contraindication to iodinated contrast or radiotracer
• • Patients unable to tolerate the supine position
• • Patients unable to provide informed consent