PEPPI Study: Identification of Women at Risk for Placental Dysfunction

Launched by OULU UNIVERSITY HOSPITAL · Oct 30, 2023

Keywords

ClinConnect Summary

The PEPPI Study is looking to identify women at risk for certain pregnancy complications, such as pre-eclampsia and intrauterine growth restriction. Researchers want to see how well a special risk calculator works, which uses information about a woman's health during her first trimester, including a blood test and blood pressure measurements. This study is open to pregnant women who are at least 18 years old, understand Finnish, and can provide consent to participate. Unfortunately, women with multiple pregnancies or those who have had a miscarriage or termination of pregnancy are not eligible.

Participants in the study can expect to provide blood samples during their first trimester and possibly again later in their pregnancy. If you are a father or child of a participating mother, there are also opportunities to take part in related studies with additional blood sampling. This research aims to help doctors better understand risks during pregnancy, which can lead to improved care for mothers and their babies.

Gender

ALL

Eligibility criteria

• • Mothers
• • Inclusion Criteria for PEPPI-study
• • Pregnant (first trimester)
• • Understands Finnish
• • ≥18 years
• • Signed informed consent
• • Exclusion Criteria
• • Multiple pregnancy
• • Miscarriage/termination of the index pregnancy
• • No first trimester blood sampling
• • Inclusion Criteria for FERPPI-study
• • Participates in PEPPI-study (criteria above)
• • Blood samples at first and third trimester of pregnancy
• • Permits blood sampling from the umbilical cord when the baby is born
• • Exclusion Criteria
• • No first or third trimester blood sampling
• • No umbilical cord blood sample after baby is born
• • Fathers
• • Inclusion Criteria
• • Biological father to the child born for the mother who participated in PEPPI study
• • ≥18 years
• • Signed informed consent
• • Exclusion Criteria
• • • Does not understand Finnish
• • Children
• • Inclusion Criteria for PEPPI-study
• • Born to mother who participated in PEPPI study
• • Signed informed consent from parent(s)
• • Exclusion Criteria
• • • No consent from parent(s)
• • Inclusion Criteria for PEPPI-offspring study • Mother in risk-, control-, or PCOS group during PEPPI-study with ultrasound information at gestational weeks 30-32 or a mother who developed pre-eclampsia during the pregnancy regardless of their study group during PEPPI-study
• • Exclusion Criteria
• • • Mother/father declines participation
• • Inclusion Criteria for FERPPI-study
• • Signed informed consent from parent(s)
• • Mother has blood samples taken at first and third trimester (iron status)
• • Child has blood samples taken at birth and at 3 months of age
• • Exclusion Criteria
• • No consent from parent(s)
• • No blood samples from mother
• • No blood samples from child