Evaluation of APOL1 Gene Variants in Kidney Donors and Their Impact on Long-term Renal Function in Donors and Recipients

Launched by HOSPITAL DO RIM E HIPERTENSÃO · Oct 31, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at a specific gene called APOL1 and how changes in this gene might affect kidney donors and the people who receive their kidneys. Researchers want to understand how common these gene changes are among living kidney donors and how they might influence the long-term health of both the donors and the transplant recipients.

If you are a living kidney donor who donated at the Hospital do Rim between January 2008 and December 2015, and you are still alive, you may be eligible to join the study. For recipients, you must have received a kidney from a living donor at the same hospital during that time frame and be at least one year post-transplant with a functioning kidney. Participants will need to sign a consent form and agree to provide some medical information for the study. This research is important because it could help improve the care and outcomes for both kidney donors and their recipients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• 1.1.1.1. Inclusion criteria 1.1.1.2. For recipients:
• • 1. Living donor kidney transplant recipients, performed at Hospital do Rim from January 1, 2008 to March 31, 2015;
• • 2. Recipients Who have reached one year after the transplant, with a functioning renal graft;
• • 3. Recipients whose donors were located agreed to participate in the research, signed the informed consent form (TCLE) and submitted to the collection of exams.
• For donors:
• • 1. Living kidney donors whose donation was made at the Hospital do Rim in the period between January 2008 and December 2015;
• • 2. That they are alive at the time the study begins;
• • 3. Who have signed the TCLE.
• Exclusion Criteria:
• * For recipients:
• • 1. Recipients who have undergone the transplant under the age of 18 years;
• • 2. Recipients who have previously undergone transplantation of other organs; 1.1.3.3. For donors: Donors Who withdraw the informed consent form at any stage of the study.