ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack
Launched by NOVO NORDISK A/S · Oct 31, 2023
Trial Information
Current as of June 14, 2025
Recruiting
Keywords
ClinConnect Summary
The ARTEMIS clinical trial is investigating a new medication called ziltivekimab, which researchers hope can help people who have recently had a heart attack. The goal is to see if ziltivekimab can lower the risk of future heart problems, like new heart attacks or strokes. Participants in the study will be randomly assigned to receive either ziltivekimab or a placebo, which is a harmless substance with no effect. They will need to give themselves an injection of the study medicine once a month for about two years.
To be eligible for this trial, participants must be at least 18 years old and have been hospitalized for a heart attack. They should also have certain medical conditions that increase their risk for further heart issues, such as a history of heart attacks, diabetes, or chronic kidney disease. It's important to note that ziltivekimab is still being studied and is not yet available for doctors to prescribe. Participants will be closely monitored throughout the study to help researchers understand how well the medication works.
Gender
ALL
Eligibility criteria
- Key inclusion:
- • Age 18 years or above at the time of signing the informed consent.
- • Hospitalisation for acute myocardial infarction with evidence of type 1 myocardial infarction (MI) by invasive angiography performed at site with percutaneous coronary intervention (PCI) capabilities.
- • ST-segment elevation myocardial infarction (STEMI) with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 12 hours before hospitalisation, at the investigator's discretion.
- • b) Electrocardiogram (ECG)-changes (in the absence of left ventricular hypertrophy or left bundle branch block): ST-segment elevation at the J point in at least two contiguous leads greater than or equal 0.25 (millivolt) mV in men less than 40 years, greater than or equal 0.2 mV in men greater than or equal 40 years, or greater than or equal 0.15 mV in women in leads V2-V3; and/or greater than or equal 0.1 mV in all other leads.
- • OR
- • Non-ST-segment myocardial infarction with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 24 hours before hospitalisation, at the investigator's discretion. b) Rise and/or fall in car-diac troponin I or T with at least one value above the 99th percentile upper reference limit.
- • Possibility for both randomisation and administration of the loading dose of study intervention as early as possible after invasive procedure, and latest within 36 hours of hospitalisation (time 0) for STEMI, and latest within 72 hours of hospitalisation (time 0) for NSTEMI.
- • Presence of at least one of the following criteria confirmed based on the participant's medical records and/or medical history interview: a) Any prior MI. b) Prior coronary revascularisation. c) Diabetes mellitus treated with ongoing glucose-lowering agent(s). d)Known chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) greater than or equal to 15 and less than 60 milliliter per minute per 1.73 square meter (mL/min/1.73 m\^2). e) Prior ischaemic stroke. f) Known carotid disease or peripheral artery disease in the lower extremities. g) Multivessel coronary artery disease (current/prior). h) For STEMI patients only: anterior MI at index acute myocardial infarction (AMI)
- Key exclusion:
- • Use of fibrinolytic therapy for treatment of the current AMI.
- • Chronic heart failure classified as being in New York Heart Association (NYHA) Class IV.
- • Ongoing haemodynamic instability defined as any of the following: a) Killip Class III or IV. b) Sustained and/or symptomatic hypotension (systolic blood pressure less than 90 millimeters of mercury (mmHg)).
- • Severe kidney impairment defined as any of the following: a) eGFR less than 15 mililitre per minute per 1.73 m\^2. b) Chronic haemodialysis or peritoneal dialysis.
- • Known alanine aminotransferase (ALT) greater than 8 x upper limit of normal (reference range) (ULN).
- • Severe hepatic disease defined as at least one of the following: a) Previously known or current hepatic encephalopathy (clinical evaluation). b) Previously known or current ascites (clinical eval-uation). c) Jaundice (clinical evaluation). d) Previous oesophageal/gastric variceal bleeding. c) Known hepatic cirrhosis.
- • Major cardiac surgical (including but not restricted to coronary artery bypass graft surgery (CABG)), non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days or any major surgical procedure planned at the time of randomisation or as treatment for the current AMI (CABG). Deferred (staged)percutaneous coronary intervention for a non-culprit vessel identified during the current AMI is allowed.
- • Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
- • Known (acute or chronic) hepatitis B or hepatitis C.
- • History or evidence of untreated latent tuberculosis (TB) such as (but not limited to): a) History of a positive TB test or chest X-ray compatible with latent TB; and TB treatment initiated less than 28 days prior to randomisation. b) Participants with TB risk factors but unwilling to undergo TB treatment if confirmed positive for latent TB based on central laboratory test at baseline (visit 2).
About Novo Nordisk A/S
Novo Nordisk A/S is a global healthcare company headquartered in Denmark, specializing in the research, development, manufacturing, and marketing of innovative pharmaceuticals, particularly in the fields of diabetes care, obesity treatment, and hormone replacement therapies. With a strong commitment to improving patient outcomes, Novo Nordisk invests significantly in clinical trials to advance scientific knowledge and develop effective therapies. The company is dedicated to sustainability and ethical practices, striving to deliver high-quality healthcare solutions while addressing the evolving needs of patients worldwide. Through collaboration and innovation, Novo Nordisk aims to lead the way in transforming diabetes and other chronic diseases into manageable conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cleveland, Ohio, United States
Epping, Victoria, Australia
Bikaner, Rajasthan, India
Nagpur, Maharashtra, India
Coimbatore, Tamil Nadu, India
Rome, , Italy
Torino, , Italy
Alor Setar, Kedah, Malaysia
Kota Samarahan, Sarawak, Malaysia
Kajang, Selangor, Malaysia
Sungai Buloh, Selangor, Malaysia
Georgetown, , Malaysia
Kota Bharu, Kelantan, , Malaysia
Kota Bharu, , Malaysia
Guadalajara, Jalisco, Mexico
Cdmx, , Mexico
San Luis Potosi, , Mexico
San Nicolas De Los Garza, , Mexico
Arnhem, , Netherlands
Breda, , Netherlands
Den Bosch, , Netherlands
Gouda, , Netherlands
Groningen, , Netherlands
Hilversum, , Netherlands
Roosendaal, , Netherlands
Rotterdam, , Netherlands
Rotterdam, , Netherlands
Lubin, , Poland
Ostrow Wielkopolski, , Poland
Pinczow, , Poland
Warsaw, , Poland
Warszawa, , Poland
Warszawa, , Poland
Wroclaw, , Poland
Sabah, , Malaysia
Cdmx, , Mexico
Monterrey, , Mexico
Frankfurt Am Main, , Germany
Nagpur, Maharashtra, India
Gotse Delchev, , Bulgaria
Haskovo, , Bulgaria
Rome, , Italy
Lovech, , Bulgaria
Plovdiv, , Bulgaria
Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Kuala Lumpur, , Malaysia
Hollywood, Florida, United States
Frankston, Victoria, Australia
Alkmaar, , Netherlands
New Delhi, Delhi, India
Petah Tikva, , Israel
Sofia, , Bulgaria
Guangzhou, Guangdong, China
Mannheim, , Germany
Athens, , Greece
Johor Bahru, Johor, Malaysia
Kuala Lumpur, , Malaysia
Przemysl, , Poland
Kuantan, Pahang, Malaysia
Los Angeles, California, United States
San Francisco, California, United States
Chaidari, Athens, , Greece
Chennai, Tamil Nadu, India
Aguascalientes, Ags, Mexico
Seoul, , Korea, Republic Of
Toruń, , Poland
Ipoh, Perak, Malaysia
Lublin, , Poland
Chennai, Tamil Nadu, India
Edinburgh, , United Kingdom
Lodz, , Poland
Ostrow Mazowiecka, , Poland
Portsmouth, , United Kingdom
Pazardzhik, , Bulgaria
Pleven, , Bulgaria
Den Haag, , Netherlands
Blagoevgrad, , Bulgaria
Nijmegen, , Netherlands
Adelaide, South Australia, Australia
Ahmedabad, , India
Jaipur, Rajasthan, India
Orange, California, United States
San Diego, California, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Peoria, Illinois, United States
Bay City, Michigan, United States
Las Vegas, Nevada, United States
Fairborn, Ohio, United States
Camp Hill, Pennsylvania, United States
Tilburg, , Netherlands
Hershey, Pennsylvania, United States
Knoxville, Tennessee, United States
Powell, Tennessee, United States
Dallas, Texas, United States
Charlottesville, Virginia, United States
Buenos Aires, , Argentina
Belo Horizonte, Minas Gerais, Brazil
Passos, Minas Gerais, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Campinas, Sao Paulo, Brazil
Morumbi, Sao Paulo, Brazil
Poços De Caldas, Minas Gerais, Brazil
Gabrovo, , Bulgaria
Aarhus N, , Denmark
Besançon Cedex, , France
Caen Cedex 9, , France
Paris, , France
Bad Berka, , Germany
Athens, , Greece
Thessaloniki, , Greece
Ostrow Wielkopolski, Wielkopolskie, Poland
Zgierz, , Poland
Poznan, , Poland
Badalona, , Spain
Winter Haven, Florida, United States
Evanston, Illinois, United States
Petoskey, Michigan, United States
Richmond, Virginia, United States
Kirdzhali, , Bulgaria
Beijing, Beijing, China
Fukuoka, , Japan
Biala Podlaska, , Poland
Dąbrowa Górnicza, śląskie, Poland
Changchun, Jilin, China
Athens, , Greece
Eindhoven, , Netherlands
Maplewood, Minnesota, United States
Birmingham, Alabama, United States
Yangsan, , Korea, Republic Of
Chandigarh, , India
Nanjing, , China
El Palmar, Murcia, Spain
Kutno, , Poland
Lodz, , Poland
Washington, District Of Columbia, United States
West Hills, California, United States
Porto Alegre, Rio Grande Do Sul, Brazil
Prague, , Czechia
Nijmegen, , Netherlands
Canton, Ohio, United States
Athens, , Greece
Bronx, New York, United States
Austin, Texas, United States
Marília, São Paulo, Brazil
Szczecin, , Poland
Stony Brook, New York, United States
Athens, , Greece
Bielsko Biała, , Poland
ústní Nad Labem, , Czechia
Surat, Gujarat, India
Bengaluru, Karnataka, India
Nagpur, Maharashtra, India
Bhubaneswar, Odisha, India
Chennai, Tamil Nadu, India
Kolkata, West Bengal, India
Puducherry, , India
Alkmaar, , Netherlands
Breda, , Netherlands
Den Bosch, , Netherlands
Den Haag, , Netherlands
Eindhoven, , Netherlands
Gouda, , Netherlands
Groningen, , Netherlands
Nijmegen, , Netherlands
Roosendaal, , Netherlands
Tilburg, , Netherlands
Rzeszow, Podkarpackie, Poland
Tupelo, Mississippi, United States
Porto Alegre/Rs, , Brazil
Vadodara, Gujarat, India
Athens, , Greece
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Norfolk, Virginia, United States
Aracaju, , Brazil
Phoenix, Arizona, United States
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Tychy, śląskie, Poland
Incheon, Incheon Gwang'yeogsi, Korea, Republic Of
Sofia, , Bulgaria
Sofia, , Bulgaria
Smolyan, , Bulgaria
Athens, , Greece
San Diego, California, United States
Rockville, Maryland, United States
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Covina, California, United States
Nagpur, Maharashtra, India
Sandanski, , Bulgaria
Sofia, , Bulgaria
Newark, Delaware, United States
Charlottesville, Virginia, United States
Warszawa, , Poland
San Antonio, Texas, United States
Milwaukee, Wisconsin, United States
Douglas, Queensland, Australia
Woolloongabba, Queensland, Australia
Vancouver, British Columbia, Canada
St. Catharines, Ontario, Canada
Shijiazhuang, Hebei, China
Plzen Lochotín, , Czechia
Shanghai, Shanghai, China
Nice, , France
Fairborn, Ohio, United States
Rome, , Italy
Berlin, , Germany
Dachau, , Germany
Dortmund, , Germany
Wuhan, Hubei, China
Bad Berka, , Germany
Nagpur, Maharashtra, India
Mexico, Estado De México, Mexico
Greenville, South Carolina, United States
Galveston, Texas, United States
Houston, Texas, United States
Randwick, New South Wales, Australia
London, Ontario, Canada
Nanning, , China
Midland, Michigan, United States
Langen, , Germany
Guadalajara, Jalisco, Mexico
Petoskey, Michigan, United States
Ciudad De México, D.F., , Mexico
Winston Salem, North Carolina, United States
Svendborg, , Denmark
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Presidente Prudente, São Paulo, Brazil
Bangor, Maine, United States
Wollongong, New South Wales, Australia
Nowy Targ, , Poland
Danbury, Connecticut, United States
Buffalo, New York, United States
New York, New York, United States
Roslyn, New York, United States
Cincinnati, Ohio, United States
Dallas, Texas, United States
Falls Church, Virginia, United States
La Plata, Buenos Aires, Argentina
Burgas, , Bulgaria
Barrie, Ontario, Canada
Bydgoszcz, , Poland
Eskisehir, Odunpazari, Turkey
Beijing, , China
Chengdu, , China
Odense C, , Denmark
Köln, , Germany
Veroia, , Greece
Vadodara, Chhattisgarh, India
Kanpur, Uttar Pradesh, India
New Delhi, , India
Sendai Shi, Miyagi, , Japan
Cheongju, , Korea, Republic Of
Kota Bharu, Kelantan, Malaysia
Warszawa, , Poland
Harefield, Middlesex, United Kingdom
Toronto, Ontario, Canada
Los Angeles, California, United States
Saint Charles Borromée, Quebec, Canada
Regina, Saskatchewan, Canada
Knoxville, Tennessee, United States
Charlottesville, Virginia, United States
Burgas, , Bulgaria
Newmarket, Ontario, Canada
København ø, , Denmark
Jackson, Mississippi, United States
Pordenone, Pn, Italy
Alessandria, , Italy
Torreon, Coahuila, Mexico
Poitiers, , France
Evanston, Illinois, United States
Lansing, Michigan, United States
Nashville, Tennessee, United States
Mexico, La Magdalena Contreras, Mexico
Hellerup, Region Hovedstaden, Denmark
Aalborg, , Denmark
Daegu, , Korea, Republic Of
Gyeonggi Do, , Korea, Republic Of
Hackensack, New Jersey, United States
Bursa, , Turkey
Pilar, Buenos Aires, Argentina
Athens, , Greece
Culiacan, Sinaloa, Mexico
Saint Paul, Minnesota, United States
Fulda, , Germany
Thessaloniki, , Greece
Little Rock, Arkansas, United States
Pontiac, Michigan, United States
Minneapolis, Minnesota, United States
Lebanon, New Hampshire, United States
Chapel Hill, North Carolina, United States
High Point, North Carolina, United States
Fargo, North Dakota, United States
Houston, Texas, United States
Tyler, Texas, United States
Richmond, Virginia, United States
Caba, Buenos Aires, Argentina, Argentina
Corrientes, Buenos Aires, Argentina
Elizabeth Vale, South Australia, Australia
Winnipeg, Manitoba, Canada
Quebec, , Canada
Beijing, , China
Chengdu, , China
Shenyang, , China
Toronto, Ontario, Canada
Larissa/Thessaly, , Greece
Paris Cedex 18, , France
Frankfurt Am Main, , Germany
Ahmedabad, Gujarat, India
Bergamo, Bg, Italy
Leipzig, , Germany
Tlalpan, Cdmx, Mexico
Guadalajara, Jalisco, Mexico
Hermosillo, Sonora, Mexico
Gdansk, , Poland
Antalya, , Turkey
Anderson, South Carolina, United States
San Donato Milanese, Mi, Italy
Murray, Utah, United States
Sofia, , Bulgaria
Berlin, , Germany
Chiba, , Japan
Georgetown, Pulau Pinang, Malaysia
Miyazaki Shi, Miyazaki, Japan
Kuantan, Pahang, Malaysia
Ostrow Wielkopolski, Wielkopolskie, Poland
Monterrey, Nuevo León, Mexico
Raleigh, North Carolina, United States
Caba, Buenos Aires, Argentina
Brampton, Ontario, Canada
Chicoutimi, Quebec, Canada
Royal Oak, Michigan, United States
Hamilton, Ontario, Canada
Lodz, , Poland
Kütahya, , Turkey
San Donato Milanese, , Italy
Opole, , Poland
New Delhi, Delhi, India
Udupi, Karnataka, India
Nashik, Maharashtra, India
Hyderabad, Telangana, India
Kanpur, Uttar Pradesh, India
Lucknow, Uttar Pradesh, India
Dehradun, Uttarakhand, India
Bron, , France
Marseille, , France
Szczecin, , Poland
Detroit, Michigan, United States
München, , Germany
Hyderabad, Telangana, India
Alexander City, Alabama, United States
Loma Linda, California, United States
Tarnow, , Poland
Gainesville, Florida, United States
Saint John, New Brunswick, Canada
Wenzhou, Zhejiang, China
Terrebonne, Quebec, Canada
Amarillo, Texas, United States
Torrance, California, United States
Sliven, , Bulgaria
Aurora, Colorado, United States
Minneapolis, Minnesota, United States
Camden, New Jersey, United States
Wuhan, Hubei, China
Changsha, Hunan, China
Thomasville, Georgia, United States
Haifa, , Israel
Cuttack, Odisha, India
Kelowna, British Columbia, Canada
Liberec, Czech Republic, Czechia
Orange, California, United States
Torrance, California, United States
New Haven, Connecticut, United States
Jacksonville, Florida, United States
Elkhart, Indiana, United States
Waterloo, Iowa, United States
Louisville, Kentucky, United States
Clinton, Maryland, United States
Atlanta, Georgia, United States
Lebanon, New Hampshire, United States
Rockford, Illinois, United States
Brooklyn, New York, United States
Elyria, Ohio, United States
Powell, Tennessee, United States
Edmonton, Alberta, Canada
Saint Charles Borromée, Quebec, Canada
Beijing, Beijing, China
San Miguel De Tucuman, Tucuman, Argentina
Wuhan, Hubei, China
Rosario, Santa Fe, , Argentina
Santa Fe, , Argentina
Tianjin, Tianjin, China
Wenzhou, Zhejiang, China
Chengdu, , China
Chengdu, , China
Hangzhou, , China
Harbin, , China
Shanghai, , China
Wuhan, Hubei, China
Changsha, Hunan, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Shenyang, , China
Tianjin, Tianjin, China
Xi'an, , China
Liberec, Czech Republic, Czechia
Paris, , France
Prague, , Czechia
Praha 4, , Czechia
Třinec, , Czechia
ústní Nad Labem, , Czechia
Erfurt, , Germany
Ampelokipoi/Athens, , Greece
Regensburg, , Germany
Athens, , Greece
Athens, , Greece
Athens, , Greece
Athens, , Greece
Piraeus, , Greece
Athens, , Greece
Chaidari, Athens, , Greece
Chios, , Greece
Thessaloniki, , Greece
Raipur, Chattisgarh, India
Goudi/Athens, , Greece
Beer Yaakov, , Israel
Torino, Piemonte, Italy
Chieti, Abruzzo, Italy
Bergamo, Lombardia, Italy
Piacenza, , Italy
Bucheon, , Korea, Republic Of
Seoul, , Korea, Republic Of
Hermosillo, Sonora, Mexico
Enschede, , Netherlands
Hilversum, , Netherlands
Konin, , Poland
Hershey, Pennsylvania, United States
Heidelberg, Victoria, Australia
Cosenza, , Italy
Latina, , Italy
South Yarra, Victoria, Australia
Napoli, , Italy
Smolyan, , Bulgaria
Dortmund, , Germany
Dresden, , Germany
Freiburg, , Germany
Hamburg, , Germany
Edmonton, Alberta, Canada
Marousi, , Greece
New Delhi, Delhi, India
Fukuoka, , Japan
Ankara, , Turkey
Incheon, , Korea, Republic Of
Seoul, , Korea, Republic Of
Hannover, , Germany
Heidelberg, , Germany
Langen, , Germany
Leipzig, , Germany
München, , Germany
Piraeus, , Greece
Amersfoort, , Netherlands
Arnhem, , Netherlands
Hilversum, , Netherlands
Rotterdam, , Netherlands
Kluczbork, , Poland
Lodz, , Poland
Warszawa, , Poland
Barcelona, , Spain
Madrid, , Spain
Santander, , Spain
Haddon Heights, New Jersey, United States
Thessaloniki, , Greece
New Delhi, Delhi, India
Ludhiana, Punjab, India
Mohali, Punjab, India
Bikaner, Rajasthan, India
Aligarh, Uttar Pradesh, India
Ahmedabad, , India
Chandigarh, , India
Gyeonggi Do, , Korea, Republic Of
Thornton, Colorado, United States
Kalamazoo, Michigan, United States
Austin, Texas, United States
Fuzhou, Fujian, China
Dallas, Texas, United States
Mcallen, Texas, United States
Mount Pleasant, Texas, United States
Plano, Texas, United States
Fairfax, Virginia, United States
Guangzhou, , China
Catanzaro, Cz, Italy
Godoy Cruz, Mendoza, Mendoza, Argentina
Rosario, Santa Fé, Argentina
Kingswood, New South Wales, Australia
Birtinya, Queensland, Australia
Salem, Virginia, United States
Sofia, , Bulgaria
Porto Alegre, Rio Grande Do Sul, Brazil
Varna, , Bulgaria
Halifax, Nova Scotia, Canada
Campinas, Sao Paulo, Brazil
Pleven, , Bulgaria
Plovdiv, , Bulgaria
Sofia, , Bulgaria
Aarhus N, , Denmark
Athens/Voula, , Greece
Ioannina, , Greece
Kifissia, , Greece
Larissa/Thessaly, , Greece
Hyogo, , Japan
Kanagawa, , Japan
Kumamoto, , Japan
Busan, , Korea, Republic Of
Xalapa, Veracruz, Mexico
Kingston, Ontario, Canada
Sudbury, Ontario, Canada
Montreal, Quebec, Canada
Alexander City, Alabama, United States
Atlanta, Georgia, United States
Decatur, Georgia, United States
Thomasville, Georgia, United States
Louisville, Kentucky, United States
Edgewood, Kentucky, United States
Asheville, North Carolina, United States
High Point, North Carolina, United States
Winston Salem, North Carolina, United States
Cincinnati, Ohio, United States
Cleveland, Ohio, United States
San Antonio, Texas, United States
Winchester, Virginia, United States
Seattle, Washington, United States
Milwaukee, Wisconsin, United States
Brampton, Ontario, Canada
Guangzhou, Guangdong, China
Hangzhou, , China
Rome, , Italy
Hokkaido, , Japan
Yokohama Shi, Kanagawa, , Japan
Gliwice, , Poland
Kluczbork, , Poland
Bursa, , Turkey
Edirne, , Turkey
Springfield, Illinois, United States
Gliwice, Slaskie, Poland
Częstochowa, , Poland
Madrid, , Spain
Santiago De Compostela, , Spain
İstanbul, , Turkey
Odunpazarı /Eskişehir, , Turkey
Shenyang, Liaoning, China
Hangzhou, , China
Harbin, , China
Shanghai, , China
Tianjin, , China
Chambray Les Tours, , France
Grenoble Cedex 9, , France
Vandoeuvre Les Nancy, , France
Bielefeld, , Germany
Aichi, , Japan
Chiba, , Japan
Chiba, , Japan
Ehime, , Japan
Himeji Shi, Hyogo, , Japan
Hyogo, , Japan
Hyogo, , Japan
Cdmx, , Mexico
Poznań, , Poland
Warsaw, , Poland
Barcelona, , Spain
Lleida, , Spain
Madrid, , Spain
Tarragona, , Spain
Chongqing, Chongqing, China
Ankara, Altindag, Turkey
Istanbul, , Turkey
Istanbul, , Turkey
Istanbul, , Turkey
Mersin, , Turkey
Portland, Maine, United States
Silver Spring, Maryland, United States
Richmond, Virginia, United States
Burgas, , Bulgaria
Nanjing City,, Jiangsu, China
Nanjing, Jiangsu, China
Ibaraki, , Japan
Kure Shi, Hiroshima, , Japan
Miyazaki Shi, Miyazaki, , Japan
Okayama, , Japan
Shiga, , Japan
Shizuoka, , Japan
Querétaro, , Mexico
Wroclaw, Dolnoslaskie, Poland
Valencia, , Spain
Rzeszow, Podkarpackie Voivodeship, Poland
Seoul, , Korea, Republic Of
Kutno, , Poland
Calgary, Alberta, Canada
Pensacola, Florida, United States
Seoul, , Korea, Republic Of
Oklahoma City, Oklahoma, United States
Marlton, New Jersey, United States
Danville, Pennsylvania, United States
Houston, Texas, United States
Greenville, South Carolina, United States
Cairns, Queensland, Australia
Southport, Queensland, Australia
Sioux Falls, South Dakota, United States
Bedford Park, South Australia, Australia
Beijing, Beijing, China
Regensburg, , Germany
Rimini, , Italy
Czestochowa, , Poland
Afyon, , Turkey
Izmit, , Turkey
Kayseri, , Turkey
Kayseri, , Turkey
Kütahya, , Turkey
Mullica Hill, New Jersey, United States
Chattanooga, Tennessee, United States
Dallas, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Sayre, Pennsylvania, United States
Jacksonville, Florida, United States
Edmonton, Alberta, Canada
Kelowna, British Columbia, Canada
Newmarket, Ontario, Canada
Stuttgart, , Germany
Nea Efkarpia, Thessaloniki, Greece
Ampelokipoi/Athens, , Greece
Goudi/Athens, , Greece
Pensacola, Florida, United States
New York, New York, United States
La Plata, Buenos Aires, Argentina
Rochester, New York, United States
Toledo, Ohio, United States
Edmonton, Alberta, Canada
Caba, City Of Buenos Aires, Argentina
St. Catharines, Ontario, Canada
Liverpool, New South Wales, Australia
Brisbane, Queensland, Australia
Ji'nan, Shandong, China
Düsseldorf, , Germany
Tianjin, Tianjin, China
Frankfurt, , Germany
Friedrichshafen, , Germany
Hamburg, , Germany
Tianjin, Tianjin, China
Fuzhou, Fujian, China
Guangzhou, , China
Dortmund, , Germany
Dresden, , Germany
Ehime, , Japan
Fukuoka Shi, Fukuoka, , Japan
Ishikawa, , Japan
Boston, Massachusetts, United States
Kanagawa, , Japan
Mount Clemens, Michigan, United States
Southfield, Michigan, United States
Minneapolis, Minnesota, United States
Omaha, Nebraska, United States
West Reading, Pennsylvania, United States
Hadera, , Israel
Tokushima, , Japan
Kanagawa, , Japan
Madrid, , Spain
İstanbul, Bakirkoy, Turkey
Montana, , Bulgaria
Trois Rivières, Quebec, Canada
Beijing, Beijing, China
Cangzhou, Hubei, China
Puducherry, , India
Kanagawa, , Japan
Takamatsu Shi, Kagawa, , Japan
Amersfoort, , Netherlands
Istanbul, , Turkey
Muratpasa/ Antalya, , Turkey
Newcastle Upon Tyne, , United Kingdom
Quebec, , Canada
Caserta, Ce, Italy
Rivoli, To, Italy
Chieti, , Italy
Osaka, , Japan
Bydgoszcz, , Poland
Vineland, New Jersey, United States
Birmingham, Alabama, United States
Brisbane, Queensland, Australia
New York, New York, United States
La Spezia, , Italy
Richmond, Virginia, United States
Sofia, , Bulgaria
Samsun, , Turkey
Tokat, , Turkey
Toronto, Ontario, Canada
Montréal, Quebec, Canada
Saskatoon, Saskatchewan, Canada
Tokyo, , Japan
Kansas City, Kansas, United States
Milano, , Italy
Ottawa, Ontario, Canada
Beijing, , China
Chongqing, , China
Buenos Aires, , Argentina
Pilar, Buenos Aires, Argentina
Quilmes, Buenos Aires, Argentina
San Nicolás De Los Arroyos, Buenos Aires, Argentina
Godoy Cruz, Mendoza, Mendoza, Argentina
San Miguel De Tucuimán, Tucumán, Argentina
Caba, , Argentina
Corrientes, , Argentina
Córdoba, , Argentina
Athens, , Greece
Larissa/Thessaly, , Greece
Guntur, Andhra Pradesh, India
Blagoevgrad, , Bulgaria
Visakhapatnam, Andhra Pradesh, India
Raipur, Chhattisgarh, India
New Delhi, Delhi, India
Ahmedabad, Gujarat, India
Mangaluru, Karnataka, India
Kochi, Kerala, India
Palakkad, Kerala, India
Mumbai, Maharashtra, India
Nagpur, Maharashtra, India
Pune, Maharashtra, India
Burgas, , Bulgaria
Jaipur, Rajasthan, India
Haskovo, , Bulgaria
Coimbatore, Tamil Nadu, India
Hyderabad, Telangana, India
Kolkata, West Bengal, India
Jerusalem, , Israel
Tel Hashomer, , Israel
Zrifin, , Israel
Napoli, , Italy
Rome, , Italy
Verona, , Italy
Daejeon, , Korea, Republic Of
Gangwon Do, , Korea, Republic Of
Gwangju, , Korea, Republic Of
Seoul, , Korea, Republic Of
Johor Bahru, Johor, Malaysia
Alor Setar, Kedah, Malaysia
Ipoh, Perak, Malaysia
Kota Samarahan, Sarawak, Malaysia
Kajang, Selangor, Malaysia
Sungai Buloh, Selangor, Malaysia
Georgetown, , Malaysia
Kota Bharu, Kelantan, , Malaysia
Pazardzhik, , Bulgaria
Kota Bharu, , Malaysia
Kuala Lumpur, , Malaysia
Wroclaw, Dolnoslaskie, Poland
Chrzanów, Małopolskie, Poland
Pleven, , Bulgaria
Plovdiv, , Bulgaria
Ruse, , Bulgaria
Sandanski, , Bulgaria
Sofia, , Bulgaria
Varna, , Bulgaria
Yambol, , Bulgaria
Corbeil Essonnes, , France
Le Coudray, , France
Lille, , France
Lyon, , France
Pessac, , France
Toulouse Cedex 9, , France
Berlin, , Germany
Bremen, , Germany
Erfurt, , Germany
Kuantan, , Malaysia
Sabah, , Malaysia
Perth, Western Australia, Australia
Brasilia, Distrito Federal, Brazil
Tsukuba Shi, Ibaraki, , Japan
Kedzierzyn Kozle, , Poland
Białystok, , Poland
Bydgoszcz, , Poland
Elbląg, , Poland
Gdańsk, , Poland
Gdynia, , Poland
Grodzisk Mazowiecki, , Poland
Guadalajara, , Mexico
Krakow, , Poland
Firenze, , Italy
Kutno, , Poland
Nowy Targ, , Poland
Houston, Texas, United States
Opole, , Poland
Middlesbrough, , United Kingdom
Dehradun, Uttarakhand, India
Ostrow Mazowiecka, , Poland
Pinczow, , Poland
Vigo, , Spain
Kanagawa, , Japan
Kolkata, West Bengal, India
Kolkata, West Bengal, India
Goyang Si, Gyeonggi Do, Korea, Republic Of
Konya, , Turkey
Mersin, , Turkey
Ostrów Mazowiecka, , Poland
Kolkata, West Bengal, India
Ypsilanti, Michigan, United States
Pensacola, Florida, United States
Duluth, Minnesota, United States
Jackson, Mississippi, United States
North Kansas City, Missouri, United States
Saint Louis, Missouri, United States
Rochester, New York, United States
Louisville, Kentucky, United States
Piraeus, , Greece
Thessaloniki, , Greece
Guntur, Andhra Pradesh, India
Visakhapatnam, Andhra Pradesh, India
Raipur, Chhattisgarh, India
New Delhi, Delhi, India
Rehovot, , Israel
Surat, Gujarat, India
Tel Aviv, , Israel
Tel Hashomer, , Israel
Zrifin, , Israel
Gwangju, , Korea, Republic Of
Cona (Ferrara), Fe, Italy
Grodzisk Mazowiecki, , Poland
Kedzierzyn Kozle, , Poland
Kluczbork, , Poland
Krakow, , Poland
Rivoli, To, Italy
Torino, To, Italy
Acquaviva Delle Fonti, , Italy
Gilbert, Arizona, United States
Fort Lauderdale, Florida, United States
Little Rock, Arkansas, United States
San Diego, California, United States
Torrance, California, United States
Teaneck, New Jersey, United States
Buffalo, New York, United States
Wroclaw, , Poland
Liverpool, New York, United States
świdnica, , Poland
Badalona, Barcelona, Spain
Badalona, , Spain
Barcelona, , Spain
Cleveland, Ohio, United States
Knoxville, Tennessee, United States
Memphis, Tennessee, United States
Nashville, Tennessee, United States
Chapel Hill, North Carolina, United States
Raleigh, North Carolina, United States
Hyderabad, Telangana, India
Hyderabad, Telangana, India
Hyderabad, Telengana, India
Aligarh, Uttar Pradesh, India
Kanpur, Uttar Pradesh, India
Lucknow, Uttar Pradesh, India
Lucknow, Uttar Pradesh, India
Wroclaw, Dolnoslaskie, Poland
Rzeszow, Podkarpackie, Poland
Białystok, , Poland
Oak Ridge, Tennessee, United States
Sheffield, , United Kingdom
Stevenage, , United Kingdom
Swansea, , United Kingdom
Taunton, , United Kingdom
Torquay, , United Kingdom
Wolverhampton, , United Kingdom
Bydgoszcz, , Poland
Czestochowa, , Poland
Elbląg, , Poland
Gdansk, , Poland
Gliwice, , Poland
Harefield, , United Kingdom
Providence, Rhode Island, United States
Fairhope, Alabama, United States
Huntsville, Alabama, United States
Mobile, Alabama, United States
Cincinnati, Ohio, United States
Kettering, Ohio, United States
Toledo, Ohio, United States
Burgas, , Bulgaria
Rapid City, South Dakota, United States
New Delhi, Delhi, India
New Delhi, Delhi, India
Truro, Cornwall, United Kingdom
Vadodara, Gujarat, India
Bengaluru, Karnataka, India
Gdynia, Pomorskie, Poland
Gdańsk, , Poland
Bournemouth, Dorset, United Kingdom
Hillerød, , Denmark
Odense C, , Denmark
Vandoeuvre Les Nancy, , France
Berlin, , Germany
Liverpool, , United Kingdom
London, , United Kingdom
Dachau, , Germany
Dortmund, , Germany
Stamford, Connecticut, United States
Verona, , Italy
Sarasota, Florida, United States
Valhalla, New York, United States
Durham, North Carolina, United States
Greensboro, North Carolina, United States
Madrid, , Spain
Minot, North Dakota, United States
Vigo, , Spain
Leicester, , United Kingdom
Bremen, , Germany
Visakhapatnam, Andhra Pradesh, India
New Delhi, Delhi, India
New Delhi, Delhi, India
Pulawy, Lubelskie, Poland
Chrzanów, Małopolskie, Poland
Krosno, , Poland
Madrid, , Spain
Bay City, Michigan, United States
Burgas, , Bulgaria
Caba, , Argentina
Caba, , Argentina
New Delhi, Delhi, India
Corrientes, , Argentina
Goudi, Athens, , Greece
Larissa/Thessaly, , Greece
Kochi, Kerala, India
Nashik, Maharashtra, India
Hadera, , Israel
Haifa, , Israel
Catanzaro, , Italy
Incheon, Incheon Gwang'yeogsi,, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Chambersburg, Pennsylvania, United States
Buenos Aires, , Argentina
Buenos Aires, , Argentina
Córdoba, , Argentina
Concord, New South Wales, Australia
Uberaba, Minas Gerais, Brazil
Recife, Pernambuco, Brazil
Nashik, Maharashtra, India
Pune, Maharashtra, India
Pune, Maharashtra, India
Bhubaneswar, Odisha, India
Cuttack, Odisha, India
Corbeil Essonnes, , France
Le Coudray, , France
Lille, , France
Lyon, , France
Pessac, , France
Toulouse Cedex 9, , France
Berlin, , Germany
Ashford, Kent, United Kingdom
Burgas, , Bulgaria
Blackpool, Lancashire, United Kingdom
Kirdzhali, , Bulgaria
São José Do Rio Preto, Sao Paulo, Brazil
Pleven, , Bulgaria
Bragança Paulista, São Paulo, Brazil
Cidade Nova Votuporanga, São Paulo, Brazil
Chios, , Greece
Plovdiv, , Bulgaria
Sofia, , Bulgaria
Ioannina, , Greece
Kifissia, , Greece
Mangaluru, Karnataka, India
Bengaluru, Karnataka, India
Plovdiv, , Bulgaria
Geelong, Victoria, Australia
Ruse, , Bulgaria
Sofia, , Bulgaria
Varna, , Bulgaria
Brno, , Czechia
Ceske Budejovice, , Czechia
Athens, , Greece
Pardubice, , Czechia
Plzen Bory, , Czechia
Praha 10, , Czechia
Hamburg, , Germany
Nea Efkarpia, Thessaloniki, Greece
Liberec, Czech Republic, Czechia
Brno, , Czechia
Praha 2, , Czechia
Praha, , Czechia
Copenhagen, , Denmark
Dresden, , Germany
Erfurt, , Germany
Frankfurt Am Main, , Germany
Freiburg, , Germany
Hannover, , Germany
Daejeon, , Korea, Republic Of
Gangwon Do, , Korea, Republic Of
Gyeonggi Do, , Korea, Republic Of
Athens, , Greece
Athens, , Greece
Kolkata, West, India
Plymouth, , United Kingdom
Köln, , Germany
Langen, , Germany
Leipzig, , Germany
Pilar, Buenos Aires, Argentina
Quilmes, Buenos Aires, Argentina
Holon, , Israel
Boise, Idaho, United States
Indianapolis, Indiana, United States
Richmond, Indiana, United States
Overland Park, Kansas, United States
Shreveport, Louisiana, United States
Springfield, Missouri, United States
Bridgewater, New Jersey, United States
Jerusalem, , Israel
Jerusalem, , Israel
Bologna, , Italy
Sofia, , Bulgaria
Pomona, New Jersey, United States
Varna, , Bulgaria
Amarillo, Texas, United States
Fairfax, Virginia, United States
Incheon, Namdong Gu, Korea, Republic Of
Plovdiv, , Bulgaria
Yambol, , Bulgaria
Augusta, Georgia, United States
Leverkusen, , Germany
Gainesville, Georgia, United States
Kanagawa, , Japan
Wroclaw, , Poland
Alicante, , Spain
Cleveland, Ohio, United States
München, , Germany
Lucknow, Uttar Pradesh, India
Bridgeport, Connecticut, United States
Los Angeles, California, United States
Xi'an, , China
Ibaraki, , Japan
Osaka, , Japan
Reggio Emilia, , Italy
Buenos Aires, , Argentina
Sofia, , Bulgaria
Ceske Budejovice, , Czechia
Olomouc, , Czechia
Pardubice, , Czechia
Heidelberg, , Germany
Athens, , Greece
Bergamo, Lombardia, Italy
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Meridian, Idaho, United States
Scottsdale, Arizona, United States
Littleton, Colorado, United States
Novara, , Italy
New Orleans, Louisiana, United States
Tupelo, Mississippi, United States
Springfield, Missouri, United States
Jersey City, New Jersey, United States
Pomona, New Jersey, United States
Zanesville, Ohio, United States
Sioux Falls, South Dakota, United States
Seattle, Washington, United States
Parma, , Italy
St Albans, Victoria, Australia
Pavia, , Italy
Uberlândia, Minas Gerais, Brazil
Rome, , Italy
Barcelona, Cataluña, Spain
Santander, , Spain
Glasgow, , United Kingdom
Vancouver, British Columbia, Canada
Goiânia, Goiás, Brazil
Kettering, , United Kingdom
Campinas, Sao Paulo, Brazil
Lincoln, , United Kingdom
Ahmedabad, Gujarat, India
Vadodara, Gujarat, India
Udupi, Karnataka, India
New Delhi, Delhi, India
New Delhi, Delhi, India
Grosseto, , Italy
Palakkad, Kerala, India
Monza, , Italy
Napoli, , Italy
Mumbai, Maharashtra, India
San Nicolás De Los Arroyos, Buenos Aires, Argentina
Ludhiana, Punjab, India
San Miguel De Tucuimán, Tucumán, Argentina
Tübingen, , Germany
Kfar Saba, , Israel
London, , United Kingdom
Mohali, Punjab, India
Genova, , Italy
Patients applied
Trial Officials
Clinical Transparency dept. 2834
Study Director
Novo Nordisk A/S
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported