ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack
Launched by NOVO NORDISK A/S · Oct 31, 2023
Trial Information
Current as of July 06, 2025
Recruiting
Keywords
ClinConnect Summary
The ARTEMIS clinical trial is investigating a new medication called ziltivekimab, which researchers hope can help people who have recently had a heart attack. The goal is to see if ziltivekimab can lower the risk of future heart problems, like new heart attacks or strokes. Participants in the study will be randomly assigned to receive either ziltivekimab or a placebo, which is a harmless substance with no effect. They will need to give themselves an injection of the study medicine once a month for about two years.
To be eligible for this trial, participants must be at least 18 years old and have been hospitalized for a heart attack. They should also have certain medical conditions that increase their risk for further heart issues, such as a history of heart attacks, diabetes, or chronic kidney disease. It's important to note that ziltivekimab is still being studied and is not yet available for doctors to prescribe. Participants will be closely monitored throughout the study to help researchers understand how well the medication works.
Gender
ALL
Eligibility criteria
- Key inclusion:
- • Age 18 years or above at the time of signing the informed consent.
- • Hospitalisation for acute myocardial infarction with evidence of type 1 myocardial infarction (MI) by invasive angiography performed at site with percutaneous coronary intervention (PCI) capabilities.
- • ST-segment elevation myocardial infarction (STEMI) with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 12 hours before hospitalisation, at the investigator's discretion.
- • b) Electrocardiogram (ECG)-changes (in the absence of left ventricular hypertrophy or left bundle branch block): ST-segment elevation at the J point in at least two contiguous leads greater than or equal 0.25 (millivolt) mV in men less than 40 years, greater than or equal 0.2 mV in men greater than or equal 40 years, or greater than or equal 0.15 mV in women in leads V2-V3; and/or greater than or equal 0.1 mV in all other leads.
- • OR
- • Non-ST-segment myocardial infarction with all the following: a) Relevant onset of symptoms suggestive of cardiac ischaemia within 24 hours before hospitalisation, at the investigator's discretion. b) Rise and/or fall in car-diac troponin I or T with at least one value above the 99th percentile upper reference limit.
- • Possibility for both randomisation and administration of the loading dose of study intervention as early as possible after invasive procedure, and latest within 36 hours of hospitalisation (time 0) for STEMI, and latest within 72 hours of hospitalisation (time 0) for NSTEMI.
- • Presence of at least one of the following criteria confirmed based on the participant's medical records and/or medical history interview: a) Any prior MI. b) Prior coronary revascularisation. c) Diabetes mellitus treated with ongoing glucose-lowering agent(s). d)Known chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) greater than or equal to 15 and less than 60 milliliter per minute per 1.73 square meter (mL/min/1.73 m\^2). e) Prior ischaemic stroke. f) Known carotid disease or peripheral artery disease in the lower extremities. g) Multivessel coronary artery disease (current/prior). h) For STEMI patients only: anterior MI at index acute myocardial infarction (AMI)
- Key exclusion:
- • Use of fibrinolytic therapy for treatment of the current AMI.
- • Chronic heart failure classified as being in New York Heart Association (NYHA) Class IV.
- • Ongoing haemodynamic instability defined as any of the following: a) Killip Class III or IV. b) Sustained and/or symptomatic hypotension (systolic blood pressure less than 90 millimeters of mercury (mmHg)).
- • Severe kidney impairment defined as any of the following: a) eGFR less than 15 mililitre per minute per 1.73 m\^2. b) Chronic haemodialysis or peritoneal dialysis.
- • Known alanine aminotransferase (ALT) greater than 8 x upper limit of normal (reference range) (ULN).
- • Severe hepatic disease defined as at least one of the following: a) Previously known or current hepatic encephalopathy (clinical evaluation). b) Previously known or current ascites (clinical eval-uation). c) Jaundice (clinical evaluation). d) Previous oesophageal/gastric variceal bleeding. c) Known hepatic cirrhosis.
- • Major cardiac surgical (including but not restricted to coronary artery bypass graft surgery (CABG)), non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days or any major surgical procedure planned at the time of randomisation or as treatment for the current AMI (CABG). Deferred (staged)percutaneous coronary intervention for a non-culprit vessel identified during the current AMI is allowed.
- • Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
- • Known (acute or chronic) hepatitis B or hepatitis C.
- • History or evidence of untreated latent tuberculosis (TB) such as (but not limited to): a) History of a positive TB test or chest X-ray compatible with latent TB; and TB treatment initiated less than 28 days prior to randomisation. b) Participants with TB risk factors but unwilling to undergo TB treatment if confirmed positive for latent TB based on central laboratory test at baseline (visit 2).
About Novo Nordisk A/S
Novo Nordisk A/S is a global healthcare company headquartered in Denmark, specializing in the research, development, manufacturing, and marketing of innovative pharmaceuticals, particularly in the fields of diabetes care, obesity treatment, and hormone replacement therapies. With a strong commitment to improving patient outcomes, Novo Nordisk invests significantly in clinical trials to advance scientific knowledge and develop effective therapies. The company is dedicated to sustainability and ethical practices, striving to deliver high-quality healthcare solutions while addressing the evolving needs of patients worldwide. Through collaboration and innovation, Novo Nordisk aims to lead the way in transforming diabetes and other chronic diseases into manageable conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
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Charlottesville, Virginia, United States
Lebanon, New Hampshire, United States
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Copenhagen, , Denmark
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Nijmegen, , Netherlands
Jacksonville, Florida, United States
Cleveland, Ohio, United States
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Athens, , Greece
Barcelona, , Spain
Madrid, , Spain
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Perth, Western Australia, Australia
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Tacoma, Washington, United States
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Napoli, , Italy
Madrid, , Spain
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Newmarket, Ontario, Canada
Madrid, , Spain
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Leicester, , United Kingdom
Heidelberg, Victoria, Australia
Leipzig, , Germany
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Edmonton, Alberta, Canada
Hannover, , Germany
Kingswood, New South Wales, Australia
Heidelberg, , Germany
Leipzig, , Germany
Eindhoven, , Netherlands
Barcelona, , Spain
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Valencia, , Spain
Erfurt, , Germany
Rochester, New York, United States
Cairns, Queensland, Australia
Seoul, , Korea, Republic Of
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Pessac, , France
Den Haag, , Netherlands
Groningen, , Netherlands
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München, , Germany
Kuala Lumpur, , Malaysia
Elizabeth Vale, South Australia, Australia
Winnipeg, Manitoba, Canada
Pleven, , Bulgaria
Roosendaal, , Netherlands
Plovdiv, , Bulgaria
Kota Bharu, Kelantan, , Malaysia
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London, , United Kingdom
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Sheffield, , United Kingdom
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Berlin, , Germany
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Seoul, , Korea, Republic Of
Gilbert, Arizona, United States
Bydgoszcz, , Poland
La Plata, Buenos Aires, Argentina
Chattanooga, Tennessee, United States
Duluth, Minnesota, United States
Langen, , Germany
Beijing, , China
Nijmegen, , Netherlands
San Antonio, Texas, United States
Ludhiana, Punjab, India
Taunton, , United Kingdom
Johor Bahru, Johor, Malaysia
München, , Germany
Shanghai, Shanghai, China
Sioux Falls, South Dakota, United States
Kuantan, Pahang, Malaysia
København ø, , Denmark
Beijing, , China
Calgary, Alberta, Canada
Shizuoka, , Japan
Portsmouth, , United Kingdom
Bay City, Michigan, United States
Wuhan, Hubei, China
Nanjing, Jiangsu, China
Milano, , Italy
Saint John, New Brunswick, Canada
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Kota Bharu, Kelantan, Malaysia
Pune, Maharashtra, India
Changsha, Hunan, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Oak Ridge, Tennessee, United States
Brno, , Czechia
Ashford, Kent, United Kingdom
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Firenze, , Italy
Jackson, Mississippi, United States
Frankfurt Am Main, , Germany
Tianjin, Tianjin, China
Daegu, , Korea, Republic Of
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Cincinnati, Ohio, United States
Lucknow, Uttar Pradesh, India
Changsha, Hunan, China
Winter Haven, Florida, United States
North Kansas City, Missouri, United States
Chambersburg, Pennsylvania, United States
Incheon, , Korea, Republic Of
Stevenage, , United Kingdom
Teaneck, New Jersey, United States
Murray, Utah, United States
Seoul, , Korea, Republic Of
Burgas, , Bulgaria
Fuzhou, Fujian, China
Liverpool, , United Kingdom
Prague, , Czechia
Sarasota, Florida, United States
Richmond, Virginia, United States
Madrid, , Spain
Springfield, Illinois, United States
Beijing, Beijing, China
Napoli, , Italy
Chongqing, , China
Rome, , Italy
St Albans, Victoria, Australia
Rome, , Italy
Buenos Aires, , Argentina
Dresden, , Germany
Seoul, , Korea, Republic Of
Kajang, Selangor, Malaysia
Guadalajara, Jalisco, Mexico
Torquay, , United Kingdom
Wuhan, Hubei, China
Corbeil Essonnes, , France
Gyeonggi Do, , Korea, Republic Of
Nijmegen, , Netherlands
Guangzhou, , China
Rosario, , Argentina
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Haskovo, , Bulgaria
Hamburg, , Germany
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Epping, Victoria, Australia
Overland Park, Kansas, United States
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Knoxville, Tennessee, United States
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Amersfoort, , Netherlands
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Nagpur, Maharashtra, India
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Atlanta, Georgia, United States
Guntur, Andhra Pradesh, India
Ludhiana, Punjab, India
Vigo, , Spain
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Lansing, Michigan, United States
Chengdu, , China
Georgetown, Pulau Pinang, Malaysia
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Hannover, , Germany
Monterrey, Nuevo León, Mexico
Birtinya, Queensland, Australia
Buffalo, New York, United States
New York, New York, United States
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Verona, , Italy
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Seoul, , Korea, Republic Of
Pune, Maharashtra, India
Pilar, Buenos Aires, Argentina
Porto Alegre, Rio Grande Do Sul, Brazil
Tianjin, Tianjin, China
San Donato Milanese, , Italy
Edirne, , Turkey
Piraeus, , Greece
Arnhem, , Netherlands
Petoskey, Michigan, United States
Kettering, , United Kingdom
London, , United Kingdom
Kota Bharu, , Malaysia
Shijiazhuang, Hebei, China
Smolyan, , Bulgaria
Jaipur, Rajasthan, India
Bucheon, , Korea, Republic Of
Parma, , Italy
Mohali, Punjab, India
Kuantan, , Malaysia
Oklahoma City, Oklahoma, United States
Vadodara, Gujarat, India
Alkmaar, , Netherlands
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Dachau, , Germany
Hillerød, , Denmark
Birmingham, Alabama, United States
Praha 4, , Czechia
Rotterdam, , Netherlands
Scottsdale, Arizona, United States
Busan, , Korea, Republic Of
Alexander City, Alabama, United States
Little Rock, Arkansas, United States
Alor Setar, Kedah, Malaysia
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Blagoevgrad, , Bulgaria
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Amersfoort, , Netherlands
Chennai, Tamil Nadu, India
Raleigh, North Carolina, United States
Corrientes, , Argentina
Beijing, Beijing, China
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Lucknow, Uttar Pradesh, India
Tarragona, , Spain
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Palakkad, Kerala, India
Seoul, , Korea, Republic Of
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Nanning, Guangxi, China
Antalya, , Turkey
Wroclaw, , Poland
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Kanagawa, , Japan
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Yangsan, , Korea, Republic Of
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Fairfax, Virginia, United States
Sioux Falls, South Dakota, United States
Xi'an, , China
Chennai, Tamil Nadu, India
Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Pune, Maharashtra, India
Genova, , Italy
Tilburg, , Netherlands
Wroclaw, , Poland
Liverpool, New York, United States
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Kolkata, West Bengal, India
Köln, , Germany
Southport, Queensland, Australia
Incheon, , Korea, Republic Of
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Minot, North Dakota, United States
Hollywood, Florida, United States
Gangwon Do, , Korea, Republic Of
Warszawa, , Poland
Cheongju, , Korea, Republic Of
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Haddon Heights, New Jersey, United States
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Rome, , Italy
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Daejeon, , Korea, Republic Of
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Athens, , Greece
Georgetown, , Malaysia
Chrzanów, , Poland
Nanjing, , China
Nanning, , China
Gyeonggi Do, , Korea, Republic Of
Olomouc, , Czechia
Chennai, Tamil Nadu, India
Guangzhou, Guangdong, China
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Daegu, Dalseo Gu, Korea, Republic Of
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Den Bosch, , Netherlands
Kota Bharu, , Malaysia
Bergamo, Bg, Italy
Richmond, Indiana, United States
Thessaloniki, , Greece
Corrientes, , Argentina
Surat, Gujarat, India
Nashik, Maharashtra, India
Bikaner, Rajasthan, India
Coimbatore, Tamil Nadu, India
Lucknow, Uttar Pradesh, India
Tel Hashomer, , Israel
Sabah, , Malaysia
Breda, , Netherlands
Plymouth, , United Kingdom
Evanston, Illinois, United States
Maplewood, Minnesota, United States
Porto Alegre, Rio Grande Do Sul, Brazil
Pensacola, Florida, United States
Chongqing, Chongqing, China
Toronto, Ontario, Canada
Lyon, , France
Seoul, , Korea, Republic Of
Gyeonggi Do, , Korea, Republic Of
Seoul, , Korea, Republic Of
Hilversum, , Netherlands
Nashik, Maharashtra, India
Ehime, , Japan
Praha, , Czechia
New Delhi, , India
Houston, Texas, United States
Udupi, Karnataka, India
Hyderabad, Telangana, India
Plovdiv, , Bulgaria
Yambol, , Bulgaria
Opole, , Poland
Novara, , Italy
Beijing, , China
Kuala Lumpur, , Malaysia
Amarillo, Texas, United States
Roosendaal, , Netherlands
Douglas, Queensland, Australia
Loma Linda, California, United States
New Delhi, Delhi, India
Waterloo, Iowa, United States
Ji'nan, Shandong, China
Rimini, , Italy
Rockville, Maryland, United States
Covina, California, United States
Athens, , Greece
Silver Spring, Maryland, United States
Krakow, , Poland
Jaipur, Rajasthan, India
Incheon, , Korea, Republic Of
Ipoh, Perak, Malaysia
Fuzhou, Fujian, China
Kochi, Kerala, India
Richmond, Virginia, United States
Thessaloniki, , Greece
Marlton, New Jersey, United States
Athens, , Greece
Gwangju, , Korea, Republic Of
Grodzisk Mazowiecki, , Poland
Seoul, , Korea, Republic Of
Santiago De Compostela, , Spain
Düsseldorf, , Germany
Powell, Tennessee, United States
Miyazaki Shi, Miyazaki, Japan
Alicante, , Spain
Quilmes, Buenos Aires, Argentina
Kolkata, West Bengal, India
Sungai Buloh, Selangor, Malaysia
Thessaloniki, , Greece
Bremen, , Germany
Dortmund, , Germany
Zrifin, , Israel
Sofia, , Bulgaria
Sandanski, , Bulgaria
Lodz, , Poland
Piraeus, , Greece
Dehradun, Uttarakhand, India
Ruse, , Bulgaria
Fairfax, Virginia, United States
Wenzhou, Zhejiang, China
Guntur, Andhra Pradesh, India
New Delhi, Delhi, India
Haskovo, , Bulgaria
Puducherry, , India
Bucheon, Gyeonggi Do, Korea, Republic Of
Orange, California, United States
Ypsilanti, Michigan, United States
Afyon, , Turkey
Stamford, Connecticut, United States
Wroclaw, Dolnoslaskie, Poland
Chrzanów, Małopolskie, Poland
Camden, New Jersey, United States
Gdansk, , Poland
Mersin, , Turkey
Kota Samarahan, Sarawak, Malaysia
Poznan, , Poland
Ankara, Altindag, Turkey
Kolkata, West Bengal, India
Monza, , Italy
Pontiac, Michigan, United States
Gabrovo, , Bulgaria
Gdansk, , Poland
Bologna, , Italy
Bergamo, Lombardia, Italy
New Delhi, Delhi, India
New Delhi, Delhi, India
Nagpur, Maharashtra, India
Royal Oak, Michigan, United States
Las Vegas, Nevada, United States
Den Bosch, , Netherlands
Catanzaro, , Italy
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Incheon, , Korea, Republic Of
Udupi, Karnataka, India
Hyderabad, Telangana, India
Kanpur, Uttar Pradesh, India
Cuttack, Odisha, India
Vadodara, Gujarat, India
Bengaluru, Karnataka, India
Bhubaneswar, Odisha, India
Tilburg, , Netherlands
Dresden, , Germany
Aligarh, Uttar Pradesh, India
Ahmedabad, , India
Rotterdam, , Netherlands
Kluczbork, , Poland
Warszawa, , Poland
Lille, , France
Pilar, Buenos Aires, Argentina
Quilmes, Buenos Aires, Argentina
San Nicolás De Los Arroyos, Buenos Aires, Argentina
Godoy Cruz, Mendoza, Mendoza, Argentina
San Miguel De Tucuimán, Tucumán, Argentina
Varna, , Bulgaria
Corbeil Essonnes, , France
Erfurt, , Germany
Larissa/Thessaly, , Greece
Raipur, Chhattisgarh, India
New Delhi, Delhi, India
Mangaluru, Karnataka, India
Palakkad, Kerala, India
Hyderabad, Telangana, India
Jerusalem, , Israel
Rome, , Italy
Johor Bahru, Johor, Malaysia
Alor Setar, Kedah, Malaysia
Ipoh, Perak, Malaysia
Kajang, Selangor, Malaysia
Georgetown, , Malaysia
Białystok, , Poland
Bydgoszcz, , Poland
Elbląg, , Poland
Gdańsk, , Poland
Gdynia, , Poland
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Kutno, , Poland
Nowy Targ, , Poland
Opole, , Poland
Ostrow Mazowiecka, , Poland
Pinczow, , Poland
Kolkata, West Bengal, India
Salem, Virginia, United States
Buenos Aires, , Argentina
Adelaide, South Australia, Australia
Campinas, Sao Paulo, Brazil
Campinas, Sao Paulo, Brazil
São José Do Rio Preto, Sao Paulo, Brazil
Pazardzhik, , Bulgaria
Plovdiv, , Bulgaria
Hellerup, Region Hovedstaden, Denmark
Le Coudray, , France
Frankfurt, , Germany
Mumbai, Maharashtra, India
Nagpur, Maharashtra, India
Dehradun, Uttarakhand, India
Acquaviva Delle Fonti, , Italy
Takamatsu Shi, Kagawa, , Japan
Gouda, , Netherlands
Bielsko Biała, , Poland
Eskisehir, Odunpazari, Turkey
Kayseri, , Turkey
Mersin, , Turkey
Rapid City, South Dakota, United States
Geelong, Victoria, Australia
Hyderabad, Telengana, India
Sungai Buloh, Selangor, Malaysia
Nea Efkarpia, Thessaloniki, Greece
New York, New York, United States
Dallas, Texas, United States
Goudi, Athens, , Greece
Gangwon Do, , Korea, Republic Of
Bron, , France
Cleveland, Ohio, United States
New Haven, Connecticut, United States
Rosario, Santa Fe, , Argentina
Hangzhou, , China
Pessac, , France
Catanzaro, Cz, Italy
Culiacan, Sinaloa, Mexico
Athens, , Greece
Athens, , Greece
Chios, , Greece
Surat, Gujarat, India
Nagpur, Maharashtra, India
Sabah, , Malaysia
Tyler, Texas, United States
Caba, , Argentina
Brasilia, Distrito Federal, Brazil
Plovdiv, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Aalborg, , Denmark
Aarhus N, , Denmark
Svendborg, , Denmark
Paris, , France
Athens, , Greece
Athens, , Greece
New Delhi, Delhi, India
Nagpur, Maharashtra, India
Kolkata, West Bengal, India
Jerusalem, , Israel
Tel Aviv, , Israel
Tel Hashomer, , Israel
Kota Samarahan, Sarawak, Malaysia
Hilversum, , Netherlands
Szczecin, , Poland
Marseille, , France
Jacksonville, Florida, United States
Bridgewater, New Jersey, United States
Caba, , Argentina
Wollongong, New South Wales, Australia
Cidade Nova Votuporanga, São Paulo, Brazil
Pleven, , Bulgaria
Sliven, , Bulgaria
Sofia, , Bulgaria
Varna, , Bulgaria
Athens, , Greece
Kifissia, , Greece
Thessaloniki, , Greece
New Delhi, Delhi, India
New Delhi, Delhi, India
Bengaluru, Karnataka, India
Nashik, Maharashtra, India
Chandigarh, , India
Cona (Ferrara), Fe, Italy
Fukuoka Shi, Fukuoka, , Japan
Kure Shi, Hiroshima, , Japan
Miyazaki Shi, Miyazaki, , Japan
Sendai Shi, Miyagi, , Japan
Tsukuba Shi, Ibaraki, , Japan
Yokohama Shi, Kanagawa, , Japan
Wroclaw, Dolnoslaskie, Poland
Grodzisk Mazowiecki, , Poland
İstanbul, Bakirkoy, Turkey
Ankara, , Turkey
Istanbul, , Turkey
Newcastle Upon Tyne, , United Kingdom
Praha 2, , Czechia
Heidelberg, , Germany
Alexander City, Alabama, United States
Fairhope, Alabama, United States
Huntsville, Alabama, United States
Los Angeles, California, United States
Littleton, Colorado, United States
Peoria, Illinois, United States
Elkhart, Indiana, United States
Tupelo, Mississippi, United States
Mullica Hill, New Jersey, United States
Houston, Texas, United States
Winchester, Virginia, United States
Seattle, Washington, United States
Milwaukee, Wisconsin, United States
Concord, New South Wales, Australia
Aracaju, , Brazil
Porto Alegre/Rs, , Brazil
Burgas, , Bulgaria
Sudbury, Ontario, Canada
Plzen Lochotín, , Czechia
Paris, , France
Dortmund, , Germany
Freiburg, , Germany
Athens, , Greece
Chaidari, Athens, , Greece
Mohali, Punjab, India
Haifa, , Israel
Zrifin, , Israel
Caserta, Ce, Italy
Rivoli, To, Italy
Torino, To, Italy
Himeji Shi, Hyogo, , Japan
Ishikawa, , Japan
Kanagawa, , Japan
Aguascalientes, Ags, Mexico
Xalapa, Veracruz, Mexico
Chrzanów, Małopolskie, Poland
Lodz, , Poland
Przemysl, , Poland
Dąbrowa Górnicza, śląskie, Poland
Tychy, śląskie, Poland
Mobile, Alabama, United States
San Diego, California, United States
Torrance, California, United States
Pensacola, Florida, United States
Gainesville, Georgia, United States
Indianapolis, Indiana, United States
Shreveport, Louisiana, United States
Bay City, Michigan, United States
Saint Louis, Missouri, United States
Chapel Hill, North Carolina, United States
Greensboro, North Carolina, United States
Cincinnati, Ohio, United States
Cleveland, Ohio, United States
Memphis, Tennessee, United States
Pilar, Buenos Aires, Argentina
San Nicolás De Los Arroyos, Buenos Aires, Argentina
Godoy Cruz, Mendoza, Mendoza, Argentina
San Miguel De Tucuimán, Tucumán, Argentina
Buenos Aires, , Argentina
Córdoba, , Argentina
Goiânia, Goiás, Brazil
Uberaba, Minas Gerais, Brazil
Uberlândia, Minas Gerais, Brazil
Recife, Pernambuco, Brazil
Bragança Paulista, São Paulo, Brazil
Presidente Prudente, São Paulo, Brazil
Blagoevgrad, , Bulgaria
Burgas, , Bulgaria
Burgas, , Bulgaria
Gotse Delchev, , Bulgaria
Kirdzhali, , Bulgaria
Lovech, , Bulgaria
Plovdiv, , Bulgaria
Ruse, , Bulgaria
Sandanski, , Bulgaria
Smolyan, , Bulgaria
Sofia, , Bulgaria
Varna, , Bulgaria
Yambol, , Bulgaria
Liberec, Czech Republic, Czechia
Brno, , Czechia
Pardubice, , Czechia
Plzen Bory, , Czechia
Praha 10, , Czechia
Odense C, , Denmark
Lille, , France
Toulouse Cedex 9, , France
Vandoeuvre Les Nancy, , France
Berlin, , Germany
Berlin, , Germany
Bremen, , Germany
Dresden, , Germany
Frankfurt Am Main, , Germany
Leverkusen, , Germany
Mannheim, , Germany
Tübingen, , Germany
Athens/Voula, , Greece
Athens, , Greece
Athens, , Greece
Athens, , Greece
Ioannina, , Greece
Larissa/Thessaly, , Greece
Piraeus, , Greece
Visakhapatnam, Andhra Pradesh, India
Raipur, Chhattisgarh, India
New Delhi, Delhi, India
New Delhi, Delhi, India
New Delhi, Delhi, India
New Delhi, Delhi, India
Ahmedabad, Gujarat, India
Vadodara, Gujarat, India
Bengaluru, Karnataka, India
Mangaluru, Karnataka, India
Nagpur, Maharashtra, India
Bhubaneswar, Odisha, India
Cuttack, Odisha, India
Bikaner, Rajasthan, India
Hyderabad, Telangana, India
Hyderabad, Telangana, India
Aligarh, Uttar Pradesh, India
Kanpur, Uttar Pradesh, India
Lucknow, Uttar Pradesh, India
Kolkata, West, India
Ahmedabad, , India
Puducherry, , India
Hadera, , Israel
Holon, , Israel
Jerusalem, , Israel
Kfar Saba, , Israel
Petah Tikva, , Israel
Rehovot, , Israel
Grosseto, , Italy
Reggio Emilia, , Italy
Rome, , Italy
Kota Bharu, Kelantan, , Malaysia
Guadalajara, Jalisco, Mexico
Cdmx, , Mexico
Cdmx, , Mexico
Monterrey, , Mexico
San Luis Potosi, , Mexico
San Nicolas De Los Garza, , Mexico
Den Haag, , Netherlands
Pulawy, Lubelskie, Poland
Rzeszow, Podkarpackie, Poland
Gdynia, Pomorskie, Poland
Czestochowa, , Poland
Elbląg, , Poland
Gdańsk, , Poland
Gliwice, , Poland
Kedzierzyn Kozle, , Poland
Kluczbork, , Poland
Krakow, , Poland
Krosno, , Poland
Kutno, , Poland
Lodz, , Poland
Lubin, , Poland
Lublin, , Poland
Nowy Targ, , Poland
Ostrow Mazowiecka, , Poland
Ostrow Wielkopolski, , Poland
Pinczow, , Poland
Toruń, , Poland
Warsaw, , Poland
Warszawa, , Poland
Warszawa, , Poland
Wroclaw, , Poland
świdnica, , Poland
Badalona, , Spain
Vigo, , Spain
Truro, Cornwall, United Kingdom
Bournemouth, Dorset, United Kingdom
Glasgow, , United Kingdom
Harefield, , United Kingdom
Sejong Si, , Korea, Republic Of
Rzeszow, Podkarpackie Voivodeship, Poland
Washington, District Of Columbia, United States
Fairborn, Ohio, United States
Camp Hill, Pennsylvania, United States
Norfolk, Virginia, United States
Belo Horizonte, Minas Gerais, Brazil
Passos, Minas Gerais, Brazil
Poços De Caldas, Minas Gerais, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Morumbi, Sao Paulo, Brazil
Marília, São Paulo, Brazil
Kirdzhali, , Bulgaria
ústní Nad Labem, , Czechia
Besançon Cedex, , France
Caen Cedex 9, , France
Rzeszow, Podkarpackie, Poland
Ostrow Wielkopolski, Wielkopolskie, Poland
Zgierz, , Poland
Badalona, , Spain
Fargo, North Dakota, United States
Izmit, , Turkey
Sofia, , Bulgaria
Warszawa, , Poland
Campinas, Sao Paulo, Brazil
Caba, City Of Buenos Aires, Argentina
Wroclaw, Dolnoslaskie, Poland
Dortmund, , Germany
Rivoli, To, Italy
Amsterdam, , Netherlands
Dallas, Texas, United States
Vandoeuvre Les Nancy, , France
Bursa, , Turkey
Ahmedabad, Gujarat, India
La Plata, Buenos Aires, Argentina
San Francisco, California, United States
Thornton, Colorado, United States
Danbury, Connecticut, United States
Jacksonville, Florida, United States
Pensacola, Florida, United States
Atlanta, Georgia, United States
Thomasville, Georgia, United States
Edgewood, Kentucky, United States
Louisville, Kentucky, United States
Portland, Maine, United States
Mount Clemens, Michigan, United States
Southfield, Michigan, United States
Minneapolis, Minnesota, United States
Omaha, Nebraska, United States
Vineland, New Jersey, United States
Asheville, North Carolina, United States
Cleveland, Ohio, United States
Greenville, South Carolina, United States
Dallas, Texas, United States
Houston, Texas, United States
Mcallen, Texas, United States
Mount Pleasant, Texas, United States
San Antonio, Texas, United States
Seattle, Washington, United States
Rosario, Santa Fé, Argentina
South Yarra, Victoria, Australia
Burgas, , Bulgaria
Montana, , Bulgaria
Sofia, , Bulgaria
Edmonton, Alberta, Canada
Edmonton, Alberta, Canada
Kelowna, British Columbia, Canada
London, Ontario, Canada
Ottawa, Ontario, Canada
St. Catharines, Ontario, Canada
Montréal, Quebec, Canada
Quebec, , Canada
Nanjing City,, Jiangsu, China
Hangzhou, , China
Hangzhou, , China
Harbin, , China
Shanghai, , China
Tianjin, , China
Chambray Les Tours, , France
Grenoble Cedex 9, , France
Bielefeld, , Germany
Friedrichshafen, , Germany
Regensburg, , Germany
Stuttgart, , Germany
Nea Efkarpia, Thessaloniki, Greece
Ampelokipoi/Athens, , Greece
Goudi/Athens, , Greece
Marousi, , Greece
Hadera, , Israel
Chieti, , Italy
La Spezia, , Italy
Rome, , Italy
Aichi, , Japan
Chiba, , Japan
Chiba, , Japan
Ehime, , Japan
Fukuoka, , Japan
Fukuoka, , Japan
Hokkaido, , Japan
Hyogo, , Japan
Hyogo, , Japan
Ibaraki, , Japan
Ibaraki, , Japan
Kanagawa, , Japan
Kanagawa, , Japan
Kanagawa, , Japan
Kanagawa, , Japan
Kumamoto, , Japan
Okayama, , Japan
Osaka, , Japan
Osaka, , Japan
Shiga, , Japan
Tokushima, , Japan
Tokyo, , Japan
Cdmx, , Mexico
Guadalajara, , Mexico
Querétaro, , Mexico
Bydgoszcz, , Poland
Czestochowa, , Poland
Częstochowa, , Poland
Gliwice, , Poland
Kluczbork, , Poland
Kutno, , Poland
Ostrów Mazowiecka, , Poland
Poznań, , Poland
Warsaw, , Poland
Lleida, , Spain
İstanbul, , Turkey
Istanbul, , Turkey
Istanbul, , Turkey
Istanbul, , Turkey
Kayseri, , Turkey
Konya, , Turkey
Kütahya, , Turkey
Muratpasa/ Antalya, , Turkey
Samsun, , Turkey
Tokat, , Turkey
Fairborn, Ohio, United States
Szczecin, , Poland
Chengdu, , China
Caba, Buenos Aires, Argentina
Amarillo, Texas, United States
Caba, Buenos Aires, Argentina, Argentina
Corrientes, Buenos Aires, Argentina
Napoli, , Italy
Krakow, , Poland
Toledo, Ohio, United States
Cincinnati, Ohio, United States
Petoskey, Michigan, United States
Pleven, , Bulgaria
Kanpur, Uttar Pradesh, India
Houston, Texas, United States
Nice, , France
Dortmund, , Germany
Knoxville, Tennessee, United States
Powell, Tennessee, United States
Sofia, , Bulgaria
Aarhus N, , Denmark
Los Angeles, California, United States
Terrebonne, Quebec, Canada
Leipzig, , Germany
Vadodara, Chhattisgarh, India
Třinec, , Czechia
Torrance, California, United States
Aurora, Colorado, United States
Thomasville, Georgia, United States
Evanston, Illinois, United States
Rockford, Illinois, United States
Detroit, Michigan, United States
Kalamazoo, Michigan, United States
Midland, Michigan, United States
Jackson, Mississippi, United States
Springfield, Missouri, United States
Jersey City, New Jersey, United States
Pomona, New Jersey, United States
Buffalo, New York, United States
New York, New York, United States
Roslyn, New York, United States
Chapel Hill, North Carolina, United States
High Point, North Carolina, United States
Raleigh, North Carolina, United States
Winston Salem, North Carolina, United States
Greenville, South Carolina, United States
Houston, Texas, United States
Plano, Texas, United States
Milwaukee, Wisconsin, United States
Randwick, New South Wales, Australia
Burgas, , Bulgaria
Burgas, , Bulgaria
Plovdiv, , Bulgaria
Varna, , Bulgaria
Kelowna, British Columbia, Canada
Brampton, Ontario, Canada
Hamilton, Ontario, Canada
Newmarket, Ontario, Canada
Chicoutimi, Quebec, Canada
Montreal, Quebec, Canada
Saint Charles Borromée, Quebec, Canada
Trois Rivières, Quebec, Canada
Quebec, , Canada
Cangzhou, Hubei, China
Liberec, Czech Republic, Czechia
Prague, , Czechia
Odense C, , Denmark
Paris Cedex 18, , France
Bad Berka, , Germany
Berlin, , Germany
Berlin, , Germany
Dachau, , Germany
Erfurt, , Germany
Frankfurt Am Main, , Germany
Fulda, , Germany
Köln, , Germany
Langen, , Germany
München, , Germany
Regensburg, , Germany
Larissa/Thessaly, , Greece
Veroia, , Greece
Haifa, , Israel
Pordenone, Pn, Italy
Alessandria, , Italy
Chiba, , Japan
Hyogo, , Japan
Tlalpan, Cdmx, Mexico
Torreon, Coahuila, Mexico
Mexico, Estado De México, Mexico
Guadalajara, Jalisco, Mexico
Mexico, La Magdalena Contreras, Mexico
Hermosillo, Sonora, Mexico
Ciudad De México, D.F., , Mexico
Gliwice, Slaskie, Poland
Bydgoszcz, , Poland
Lodz, , Poland
Tarnow, , Poland
Bursa, , Turkey
Odunpazarı /Eskişehir, , Turkey
Harefield, Middlesex, United Kingdom
Tianjin, Tianjin, China
Lebanon, New Hampshire, United States
Pleven, , Bulgaria
Tychy, , Poland
Wuhan, Hubei, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Wenzhou, Zhejiang, China
Xi'an, , China
Chios, , Greece
Thessaloniki, , Greece
Athens, , Greece
Athens, , Greece
Athens, , Greece
Chaidari, Athens, , Greece
Jacksonville, Florida, United States
Clinton, Maryland, United States
Brooklyn, New York, United States
Elyria, Ohio, United States
San Miguel De Tucuman, Tucuman, Argentina
Santa Fe, , Argentina
Edmonton, Alberta, Canada
Saint Charles Borromée, Quebec, Canada
Beijing, Beijing, China
Wuhan, Hubei, China
Tianjin, Tianjin, China
Chengdu, , China
Chengdu, , China
Harbin, , China
Shanghai, , China
Shenyang, , China
Liberec, Czech Republic, Czechia
ústní Nad Labem, , Czechia
Ampelokipoi/Athens, , Greece
Athens, , Greece
Goudi/Athens, , Greece
Ioannina, , Greece
Kifissia, , Greece
Larissa/Thessaly, , Greece
Raipur, Chattisgarh, India
Beer Yaakov, , Israel
Chieti, Abruzzo, Italy
Torino, Piemonte, Italy
Cosenza, , Italy
Latina, , Italy
Piacenza, , Italy
Hermosillo, Sonora, Mexico
Hilversum, , Netherlands
Konin, , Poland
Minneapolis, Minnesota, United States
Sofia, , Bulgaria
Kuantan, Pahang, Malaysia
Ostrow Wielkopolski, Wielkopolskie, Poland
Kütahya, , Turkey
Sofia, , Bulgaria
Buenos Aires, , Argentina
Ceske Budejovice, , Czechia
Pardubice, , Czechia
Cidade Nova Votuporanga, , Brazil
Bragança Paulista, , Brazil
Dąbrowa Górnicza, , Poland
San Miguel De Tucuimán, , Argentina
Goiânia, , Brazil
Marília, , Brazil
Presidente Prudente, , Brazil
Mexico, , Mexico
El Palmar, Murcia, Spain
Columbia, Missouri, United States
Charlotte, North Carolina, United States
Virginia Beach, Virginia, United States
Zlín, , Czechia
Eleusina, , Greece
Patra, , Greece
Tripoli, , Greece
Piacenza, , Italy
Patients applied
Trial Officials
Clinical Transparency dept. 2834
Study Director
Novo Nordisk A/S
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported