Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrtho)

Launched by ISTITUTO ORTOPEDICO RIZZOLI · Nov 6, 2023

Keywords

ClinConnect Summary

This clinical trial, called GlycOrtho, is studying how major spine surgery affects a specific part of our blood vessels, known as the endothelial glycocalyx, by measuring a substance called Syndecan-1. The researchers want to find out how much this protective layer is damaged during surgery and if the level of damage varies among different groups of patients, such as those with scoliosis or degenerative spine diseases.

If you or a loved one is considering major spine surgery and meets certain criteria—like being able to understand and sign consent forms and having a blood loss of more than 25% during the procedure—you might be eligible to participate. Participants will have blood samples taken at various times, including before and after surgery, to help the researchers gather important information. This study could provide valuable insights into how spine surgery impacts blood vessel health, which can improve patient care in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Undergoing Major Spine Surgery with estimated blood loss\> 25% of total blood volume
• • American Society of Anesthesiology status 1-2-3
• • Able to comprehend and sign informed consent.
• • If age \<18 years: parent or legal representative able to comprehend and sign informed consent
• Exclusion Criteria:
• • Surgery outside of laboratory opening hours
• • Patients undergoing spine surgery for genetic syndromes/neuromuscular scoliosis