Hyper-Spectral Endoscopy for Detection of Early Neoplasia in Barrett's Oesophagus

Launched by UNIVERSITY OF CAMBRIDGE · Oct 31, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating a special type of imaging called hyperspectral endoscopy to help doctors better identify early signs of cancer in the esophagus, particularly in patients with Barrett's esophagus. Barrett's esophagus is a condition where the lining of the esophagus changes and can lead to cancer. The trial aims to see how well this new imaging technique can tell the difference between cancerous and non-cancerous areas during an endoscopy, which is a procedure where a thin tube with a camera is inserted into the esophagus.

To participate in this study, individuals must be at least 18 years old and have been diagnosed with Barrett's esophagus, with certain criteria regarding the length of the affected area. Participants will first have a standard endoscopy, followed by the new imaging procedure. They may also have some tissue samples taken for further testing. It’s important to note that people with specific health conditions, such as certain liver problems or those who have had certain surgeries, may not be eligible to join. This trial is not yet recruiting participants, but it aims to improve early detection of esophageal cancer, which could lead to better treatment outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female subjects over 18 years.
• • Previous diagnosis of Barrett's oesophagus, with an endoscopic length of at least 2 cm if circumferential (C≥2 according to Prague classification) or 3 cm if not circumferential (maximal extent M≥3, according to Prague classification).
• • Previous diagnosis of oesophageal glandular dysplasia or early oesophageal adenocarcinoma for consideration of endoscopic therapy.
• Exclusion Criteria:
• • History of oesophageal stricture precluding passage of the endoscope.
• • Pregnancy, or planned pregnancy during the course of the study.
• • Currently breastfeeding.
• • Any history of oesophageal varices, liver impairment of moderate or worse severity (Child's- Pugh class B \& C) or evidence of varices on initial treatment endoscopy.
• • Any history of oesophageal surgery, except for uncomplicated fundoplication.
• • History of coagulopathy, with INR\>1.3 and/or platelet count of \<75,000.
• • On clopidogrel, and/or warfarin for high risk condition and unable to withhold temporarily the medication.