Molecular Mechanisms Underpinning Sarcopenic Obesity

Launched by THE SWEDISH SCHOOL OF SPORT AND HEALTH SCIENCES · Nov 1, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a condition called sarcopenic obesity, which occurs when someone is both obese and has low muscle mass, often seen in older adults. The researchers want to understand how this condition affects muscle and blood health compared to older adults who are either obese without muscle loss or lean with healthy muscle. They hope to gather important information that can help improve the health of older adults dealing with these issues.

To participate in the trial, individuals must be between 65 and 74 years old, free from certain serious health conditions, and able to walk and perform specific exercises without help. Participants will be involved in assessments related to their muscle and blood health. This study is currently recruiting, and it’s a great opportunity for those who meet the criteria to contribute to valuable research that could lead to better care for older adults facing sarcopenic obesity.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Body fat % in accordance with previously defined criteria
• • Free of smoking (since 10 years)
• • Able to walk without assistance
• • Able to perform bilateral leg extension exercise
• Exclusion Criteria:
• • History of or present disease of myocardial, vascular, endocrine, hepatic, renal, pulmonary or neuromuscular origin
• • Uncontrolled hypo/hypertension
• • Use of anticoagulants (Warfarin, Trombyl)
• • Use of metformin or other anti-diabetic medications
• • Poor appetite and unexplained weight loss (4,5 kg) over the past 6 months
• • Active malignancy
• • Present infection
• • Dementia or delirium
• • Other conditions that may interfere with the study protocol in the opinion of the PI