Brain MRI Imaging Changes and Associated Factors on Cognition Function in Patients With Premature Ovarian Failure

Launched by INTERNATIONAL PEACE MATERNITY AND CHILD HEALTH HOSPITAL · Nov 2, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how changes in brain imaging, specifically MRI scans, might affect thinking and memory in women with a condition called premature ovarian failure (POF). POF occurs when a woman's ovaries stop working before the age of 40, which can lead to various symptoms and health issues. Researchers want to understand how these brain changes are linked to cognitive function, or how well someone can think and remember.

Women aged 18 to 40 who have been diagnosed with POF can participate in this study. To qualify, they need to have specific hormone levels confirmed by blood tests and must be able to give their consent to join. The study will also include a comparison group of healthy women who are similar in age and other factors but do not have POF. Participants in the trial will undergo MRI scans and answer questions about their health, and they can expect to contribute valuable information that could help improve understanding and treatment of POF. It’s important to note that some women, such as those who are pregnant or have certain medical conditions, will not be eligible to join the study.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• 1. Criteria for premature ovarian failure:
• 1. Subjects must meet all the following criteria to be included in the study:
• • 2. Female, between 18 and 40 years old;
• • 3. FSH ≥ 40U/L on two occasions at least four weeks;
• • 4. Sign informed consent. 2. Criteria for the health control group: According to the case control principle, at the same time, the investigators select women with similar age, BMI, working environment, education level and regular menstrual cycle in our hospital, and conduct endocrine examination (FSH \<10U/L) for health examination.
• Exclusion Criteria:
• • 1. Pregnancy or lactation;
• • 2. Patients with secondary ovarian insufficiency (such as causes of the hypothalamus);
• • 3. Chromosomal karyotype abnormalities (such as Turner syndrome, brittle X syndrome);
• • 4. Any disease that requires immediate blood transfusion;
• • 5. Abuse of alcohol, drugs or drugs (for example, laxatives)
• • 6. Allergies to MRI contrast agents;
• • 7. Accompanied by metal implants, claustrophobia and other magnetic resonance scanning contraindications;
• • 8. Accompanied by serious brain organic diseases, such as epilepsy, stroke, encephalitis, brain trauma, and so on. Nervous system diseases, such as Parkinson's disease, have other cognitive-impacting diseases, or serious somatic diseases such as malignant tumors, acute heart failure, multi-organ failure, and so on.