Introduction of Y90-PET-CT Post Radioembolisation Therapy Scans

Launched by THE CHRISTIE NHS FOUNDATION TRUST · Nov 7, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new type of scan called Y90-PET-CT to see if it can provide better images after treatment for liver cancer using Yttrium-90 microspheres. In this treatment, tiny radioactive beads are placed in the liver to target and damage cancer cells while sparing healthy tissue. The trial will involve a small number of patients who are already receiving this therapy, and they will have two scans after their treatment: one with the current method and one with the new Y90-PET-CT scan. The goal is to find out if the new scan gives clearer and more accurate information about how well the treatment is working.

To be eligible for this trial, participants should be between 18 and 85 years old and must be scheduled to receive Y90-microsphere therapy for liver cancer. However, individuals with claustrophobia or those who may have difficulty lying still for about 45 minutes in the scanner won’t be able to participate. Patients who join the trial can expect to have both types of scans and to receive close monitoring to see how well the new imaging method performs. This research could lead to better monitoring and treatment options for patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing liver treatment Y90-Microspheres therapy.
• • Male or female
• • Aged 18-85 years
• Exclusion Criteria:
• A participant will not be eligible for inclusion in this study if any of the following criteria apply:
• • History of, or suffers from, claustrophobia or participant feels unable to lie flat and still on their back for a period of up to 45 minutes in the scanner;
• • o Priority will be given to their current clinical care scan Y-90-bremsstrahlung-SPECT
• • In the opinion of the clinical team, they are unlikely to comply with the study protocol and restrictions that it imposes (i.e. patient uncomfortable to withstand a double scan on the day); Female participants of childbearing potential must confirm they are not pregnant (a strict requisite before 90Y-therapy anyway).