Innovative Application of Pressure Gradient Measurement in Internal Carotid Stenosis in Patients Undergoing CAS

Launched by 4TH MILITARY CLINICAL HOSPITAL WITH POLYCLINIC, POLAND · Nov 3, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to measure blood flow in patients with carotid artery stenosis, which is a narrowing of the arteries in the neck that can lead to strokes. The main goal is to find out if measuring the pressure in these arteries can help doctors decide which patients would benefit most from a procedure called carotid artery stenting (CAS), where a small tube is placed to open up the artery. This is important because while some patients may have significant narrowing, not everyone will benefit from the procedure, and the trial aims to identify those who will.

To be eligible for this study, participants must be adults over 18 with a certain level of carotid artery narrowing—more than 50% for those experiencing symptoms and more than 60% for those without symptoms. All interested patients will need to give their consent to participate. During the trial, participants can expect assessments before and after the CAS procedure, including tests for blood flow to the brain, cognitive function, and other neurological symptoms. This research could help improve how doctors assess and treat patients at risk for stroke due to carotid artery issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Stenosis of the internal carotid artery in symptomatic patients: \> 50%, (confirmed by non-invasive imaging studies: USG, angio-CT), qualified for angioplasty with stent implantation
• • Stenosis of the internal carotid artery in asymptomatic patients: \>60%, (confirmed by non-invasive imaging studies: USG, angio-CT), qualified for angioplasty with stent implantation
• • Age of patients: \> 18 years of age
• • Provided informed consent to participate in the study.
• Exclusion Criteria:
• • Inability to obtain informed consent to participate in the study.
• • Difficult anatomy of the aortic arch and the descending cephalic arteries (increased atherosclerotic lesions, acute angle of departure of the common carotid arteries, kinking of the internal carotid arteries).