Adenomyosis Patients With Infertility and Immunological Factors

Launched by PEKING UNIVERSITY THIRD HOSPITAL · Nov 8, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the relationship between adenomyosis—a condition where the tissue that normally lines the inside of the uterus grows into the muscle wall of the uterus—and infertility, particularly looking at how immune factors might play a role. Women aged 18 to 40 who have been diagnosed with adenomyosis and have regular menstrual cycles may be eligible to participate. However, women with certain other uterine conditions, systemic diseases, or severe endocrine or immune disorders will not be able to join the study.

Participants in this trial will undergo in vitro fertilization (IVF), a process where an egg is combined with sperm outside the body to help with conception. Blood samples will be taken on specific days during the process to study the immune system's response. If a pregnancy test is positive, additional blood samples will be collected to track changes throughout the early stages of pregnancy. Overall, this study aims to better understand how immune factors influence infertility in women with adenomyosis, which could lead to improved treatments in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients were diagnosed as adenomyosis by transvaginal ultrasound scans (The criteria for sonographic diagnosis of adenomyosis are with 2 or more of the following: heterogeneous myometrial texture with the presence of globular asymmetric uterus, thickening of the anterior and posterior myometrial wall, irregular cystic areas within the myometrium);
• • 18≤ age ≤ 40 years old at first outpatient visit in our Reproductive Center;
• • with regular menstrual cycle.
• Exclusion Criteria:
• • Patients with intrauterine adhesion, uterine malformation, submucosal leiomyoma, or ≥ 5.0 cm in diameter leiomyoma;
• • hydrosalpinx and systemic diseases;
• • patients with other endocrine severe diseases, immune diseases, tumors and abnormal chromosomes in either partner.