Androgens and NAFLD Longitudinal Cohort Study

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Nov 3, 2023

Keywords

ClinConnect Summary

The Androgens and NAFLD Longitudinal Cohort Study is researching how androgens, which are hormones in the body, may influence a liver condition called nonalcoholic fatty liver disease (NAFLD) in young women over time. NAFLD occurs when too much fat builds up in the liver, which can lead to liver damage. This study is particularly focused on young women with polycystic ovary syndrome (PCOS), a condition that increases the risk of developing NAFLD and is often linked to higher levels of androgens. The researchers will compare the liver health of young women with PCOS to those without PCOS to see how these factors interact.

If you are a young woman aged between 18 and 40 and have either PCOS or a liver condition called metabolic associated steatohepatitis (MASH), you could be eligible to participate. However, if you drink more than seven alcoholic drinks a week, are currently pregnant, or have lost more than 10% of your body weight in the last six months, you may not qualify. Participants will be monitored over time to see how their liver health changes, helping researchers gain insights into the relationship between androgens and liver conditions. This study is funded by the National Institutes of Health and is actively recruiting participants.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Metabolic associated steatohepatitis (MASH) (formerly NASH)
• • PCOS
• • Non-PCOS
• Exclusion Criteria:
• • High levels of alcohol use (more than 7 drinks a week)
• • Current pregnancy
• • Other causes of hepatic steatosis
• • Weight loss of more than 10% body weight in the last 6 months